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Form follows function: a computational simulation exercise on bone shape forming and conservation

Mittag, Uwe and Kriechbaumer, Andreas and Bartsch, Marion and Rittweger, Jörn (2015) Form follows function: a computational simulation exercise on bone shape forming and conservation. Journal of Musculoskeletal and Neuronal Interactions, 15 (2), pp. 215-226. International Society of Musculoskeletal and Neuronal Interactions. ISSN 1108-7161.

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The present paper explores whether the shape of long bone shafts can be explained as a mere result of mechano-adapation. A computer simulation study was conducted in order to investigate adaptation processes of bone-like structures under load patterns comparable to those acting on the diaphysis of long bones. The aim of the study was to have a deeper look into the relationship between typical loading patterns and resulting bone shape and structure. The simulations are based on a mechanistic model approach for mechano-transduction and bone transformation. Results of the simulations are that axial torsion around the long axis is important for the evolvement and maintenance of tube-like structures. Of note such structures can form from a variety of starting geometries, provided that axial torsion is present. The selection of the set-point parameter for the regulation of load adapted bone transformation has an impact on the final structure as well. In conclusion, the present study confirms the mechanical environment's potential to generate shaft-like structures and demonstrates the respective boundary conditions

Item URL in elib:https://elib.dlr.de/98269/
Document Type:Article
Title:Form follows function: a computational simulation exercise on bone shape forming and conservation
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Date:June 2015
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:pp. 215-226
Publisher:International Society of Musculoskeletal and Neuronal Interactions
Keywords:Bone Adaptation, Mechanostat, In Silico Study, Structural Mechanics, Bone Modelling
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Institute of Materials Research > Experimental and Numerical Methods
Deposited By: Bartsch, Dr.-Ing. Marion
Deposited On:22 Sep 2015 09:55
Last Modified:10 Jan 2019 15:51

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