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Pulse Contour Methods to Estimate Cardiovascular Indices in Micro- And Hypergravity

Arai, Tatsuya and Limper, Ulrich and Gauger, Peter and Beck, L. (2013) Pulse Contour Methods to Estimate Cardiovascular Indices in Micro- And Hypergravity. Aviation, Space and Environmental Medicine, 84 (11), pp. 1178-1185. Aerospace Medical Association. doi: 10.3357/ASEM.3683.2013. ISSN 0095-6562.



Background: The importance of noninvasive health monitoring in space increased as a result of the long-duration missions on the International Space Station (ISS). In order to monitor changes in cardiovascular indices such as cardiac output (CO) and total peripheral resistance (TPR), many methods have been developed using signal processing and mathematical modeling techniques. However, their performance in various gravitational conditions has not been known. Methods: The present study compared 10 methods to estimate CO and TPR by processing peripheral arterial blood pressure signals recorded from 8 subjects in multiple gravity levels (1 G, 0 G, and 1.8 G) during parabolic fl ights. For reference data sets, CO and TPR were simultaneously obtained by an inert gas rebreathing technique. Root normalized mean square errors and Bland-Altman plots were used to evaluate the estimation methods. Results: The corrected impedance method achieved the lowest estimation errors (20.0% CO error and 23.5% TPR error) over the three gravity levels. In microgravity, mean arterial pressure was also demonstrated to be an indicator of CO (24.5% error). Discussion: The corrected impedance method achieved low estimation errors for a wide range of the gravity levels. Gravity-dependent performance was observed in the mean arterial pressure method that achieved low errors in the shortterm 0 G.

Item URL in elib:https://elib.dlr.de/85129/
Document Type:Article
Title:Pulse Contour Methods to Estimate Cardiovascular Indices in Micro- And Hypergravity
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Limper, UlrichUlrich.Limper (at) dlr.deUNSPECIFIED
Date:November 2013
Journal or Publication Title:Aviation, Space and Environmental Medicine
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In ISI Web of Science:No
DOI :10.3357/ASEM.3683.2013
Page Range:pp. 1178-1185
Publisher:Aerospace Medical Association
Keywords:inert gas rebreathing , parabolic fl ight , cardiac output , total peripheral resistance .
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:15 Nov 2013 12:28
Last Modified:31 Jul 2019 19:42

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