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Spongy bone structure and mechanical response

Heinig, Christin and Bartsch, Marion and Mittag, U. and Rittweger, Jörn and Ganesan, Kathirvel and Dennstedt, A. and Ratke, Lorenz (2013) Spongy bone structure and mechanical response. 19th IAA Humans in Space, 07.-12. July 2013, Koeln, Deutschland.

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Abstract

Humans in space suffer from losses of bone mass accompanied by bone restructuration. The structural adaption depends on prevailing loading conditions. It can be assumed that the resulting structure is optimized with respect to the given restrictions, which are governed by biological mechanisms. It is not understood how structure and mechanical properties of cancellous bone are linked and how the structure can be characterized precisely. The challenges are the complex spongy architecture of the bone as well as the anisotropy of mechanical properties of the trabeculae due to their evolution from collagen fibrils. For achieving a better understanding of dependence between structure and mechanical response researchers from 3 DLR-Institutes work together. We expect to gain insight in remodelling mechanisms, which can be considered as load dependent structural optimization processes. The knowledge can be translated into adapting the load, e.g. by systematic physical training of astronauts, for avoiding losses of bone mass under microgravity. The gained knowledge will be also utilized for producing artificial bone material adapted to external mechanical loads. Subject of first investigations were bovine tail vertebrae. By means of X-ray tomography 3-dimensional images of samples from trabecular bone tissue were generated and analysed for identifying geometric parameters characterizing the microstructure. An approach was selected, which describes the microstructure as material with irregularly shaped pores characterized by largest and smallest diameters and orientation of the axis along the largest extension. Global parameters such as density and elastic constants of the bone samples were determined on 3-dimensional numerical models. Using the microstructural parameters we calculated new bone structure models and compared their global parameters with those derived from real bone samples. We found that the global properties of calculated and real bone structure models matched well, indicating that the calculated models are appropriate for further studies on the influence of microstructural parameters on mechanical properties. Further investigations will include mechanical tests on real bone tissue samples for identifying the anisotropy effect of the trabeculae. The results of these analyses will be utilized when designing artificial bones from the new material class of aerogels for further developing spongy nano cellulose felt materials resembling cancellous bone.

Item URL in elib:https://elib.dlr.de/83591/
Document Type:Conference or Workshop Item (Poster)
Title:Spongy bone structure and mechanical response
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Heinig, ChristinDLR WF (ENM)UNSPECIFIED
Bartsch, Marionmarion.bartsch (at) dlr.deUNSPECIFIED
Mittag, U.uwe.mittag (at) dlr.deUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Ganesan, Kathirvelkathrivel.ganesan (at) dlr.deUNSPECIFIED
Dennstedt, A.anne.dennstedt (at) dlr.deUNSPECIFIED
Ratke, Lorenzlorenz.ratke (at) dlr.deUNSPECIFIED
Date:10 July 2013
Refereed publication:No
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Spongy bone, microstructure, trabecular structure, parametric microstructure model, mechnical behaviour, artificial bone, aerogel, bone remodelling
Event Title:19th IAA Humans in Space
Event Location:Koeln, Deutschland
Event Type:international Conference
Event Dates:07.-12. July 2013
Organizer:Institute of Aerospace Medicine, German Aerospace Centrer
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Materials Research > Experimental and Numerical Methods
Deposited By: Bartsch, Dr.-Ing. Marion
Deposited On:29 Aug 2013 11:24
Last Modified:27 Oct 2014 10:03

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