alpha-Synuclein conformations as novel biomarkers in blood of PD patients

de Boni, Laura and Ruiz-Riquelme, Alejandro and Hays Watson, Aurelia and Leyland, Louise-Ann and Bourinaris, Thomas and Wüllner, Ullrich and Houlden, Henry and Weil, Rimona S. and Bartels, Tim (2022) alpha-Synuclein conformations as novel biomarkers in blood of PD patients. AD/PD, 2022-03-15 - 2022-03-20, Spanien.

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Abstract

We assessed the αSYN tetramer/monomer ratios in asymptomatic G51D carriers, idiopathic PD patients and healthy controls. Interestingly, the αSYN tetramer/monomer ratio is already decreased in the asymptomatic G51D carriers being at risk to develop PD. This supports the hypothesis that αSYN multimer destabilization precedes the development of clinical PD. We were also able to detect a significant decrease in αSYN tetramer/monomer ratios in idiopathic PD patients compared to controls.

Item URL in elib:

https://elib.dlr.de/211349/

Document Type:

Conference or Workshop Item (Speech)

Title:

alpha-Synuclein conformations as novel biomarkers in blood of PD patients

Authors:

Authors	Institution or Email of Authors	Author's ORCID iD	ORCID Put Code
de Boni, Laura	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Ruiz-Riquelme, Alejandro	UK Dementia Research Institute, University College London London	https://orcid.org/0000-0001-6581-7132	UNSPECIFIED
Hays Watson, Aurelia	UK Dementia Research Institute, University College London London	UNSPECIFIED	UNSPECIFIED
Leyland, Louise-Ann	University College London	UNSPECIFIED	UNSPECIFIED
Bourinaris, Thomas	University College London	UNSPECIFIED	UNSPECIFIED
Wüllner, Ullrich	German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Department of Neurodegenerative Diseases and Gerontopsychiatry, University Hospital Bonn, Bonn, Germany	UNSPECIFIED	UNSPECIFIED
Houlden, Henry	University College London	UNSPECIFIED	UNSPECIFIED
Weil, Rimona S.	University College London	https://orcid.org/0000-0002-5092-6325	UNSPECIFIED
Bartels, Tim	UNSPECIFIED	https://orcid.org/0000-0002-4071-5612	UNSPECIFIED

Date:

2022

Refereed publication:

Yes

Open Access:

Yes

Gold Open Access:

In SCOPUS:

In ISI Web of Science:

Status:

Published

Keywords:

Protein, Formen, Parkinson

Event Title:

AD/PD

Event Location:

Spanien

Event Type:

international Conference

Event Start Date:

15 March 2022

Event End Date:

20 March 2022

HGF - Research field:

other

HGF - Program:

other

HGF - Program Themes:

other

DLR - Research area:

Digitalisation

DLR - Program:

D - no assignment

DLR - Research theme (Project):

D - no assignment

Location:

Köln-Porz

Institutes and Institutions:

Institute of Aerospace Medicine
Institute of Aerospace Medicine > Office of Management and Budget

Deposited By:

de Boni, Laura

Deposited On:

14 Jan 2025 14:11

Last Modified:

14 Jan 2025 14:11

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