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Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging

Manuel, J. and Halbe, E. and Ewald, A.C. and Hoff, A. and Jordan, J. and Tank, J. and Heusser, K. and Gerlach, D.A. (2023) Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging. Frontiers in Neuroscience, 17, p. 1297197. Frontiers Media S.A.. doi: 10.3389/fnins.2023.1297197. ISSN 1662-4548.

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Official URL: https://www.frontiersin.org/articles/10.3389/fnins.2023.1297197/abstract

Abstract

Hypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans. We developed an approach to assess hypothalamic functional connectivity changes during glucose loading using functional magnetic resonance imaging (fMRI). To do so, we conducted oral glucose tolerance tests while acquiring functional images before, and 10 and 45 minutes after glucose ingestion in a healthy male and cross-sectionally in 20 healthy participants on two different diets. At group level, 39 fMRI sessions were not sufficient to detect glucose-mediated connectivity changes. However, ten repeated sessions in a single subject revealed significant intrinsic functional connectivity increases 45 minutes after glucose intake in the arcuate, paraventricular, and dorsomedial nuclei, as well as in the posterior hypothalamic area, median eminence, and mamillary bodies. Our methodology allowed to outline glucose-sensitive hypothalamic pathways in a single human being and holds promise in delineating individual pathophysiology mechanisms in patients with dysglycemia.

Item URL in elib:https://elib.dlr.de/199965/
Document Type:Article
Title:Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Manuel, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halbe, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewald, A.C.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Hoff, A.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Tank, J.UNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Heusser, K.UNSPECIFIEDhttps://orcid.org/0000-0002-2571-5585UNSPECIFIED
Gerlach, D.A.UNSPECIFIEDhttps://orcid.org/0000-0001-7044-6065UNSPECIFIED
Date:December 2023
Journal or Publication Title:Frontiers in Neuroscience
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:17
DOI:10.3389/fnins.2023.1297197
Page Range:p. 1297197
Publisher:Frontiers Media S.A.
ISSN:1662-4548
Status:Published
Keywords:fMRI, Hypothalamus, Energy Metabolism, Glucose regulation, functional connectivity, glucose-sensitive neural circuits, Oral glucose tolerance test
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:05 Dec 2023 17:04
Last Modified:16 Jan 2024 10:21

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