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Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest

Hönemann, J. and Möstl, S. and Diedrich, A. and Mulder, E. and Frett, T. and Petrat, G. and Pustowalow, W. and Arz, M. and Schmitz, M.T. and Heusser, K. and Lee, S.M.C. and Jordan, J. and Tank, J. and Hoffmann, F. (2023) Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest. Frontiers in cardiovascular medicine, 10, p. 1250727. Frontiers Media S.A.. doi: 10.3389/fcvm.2023.1250727. ISSN 2297-055X.

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Official URL: https://doi.org/10.3389/fcvm.2023.1250727

Abstract

Impaired cardiovascular autonomic control following space flight or immobilization may limit the ability to cope with additional hemodynamic stimuli. Head-down tilt bedrest is an established terrestrial analog for space flight and offers the opportunity to test potential countermeasures for autonomic cardiovascular deconditioning. Previous studies revealed a possible benefit of daily artificial gravity on cardiovascular autonomic control following head-down tilt bedrest, but there is a need for efficiency in a long-term study before an artificial gravity facility would be brought to space. We hypothesized that artificial gravity through short-arm centrifugation attenuates functional adaptions of autonomic function during head-down tilt bed rest. 24 healthy persons (8 women, 33.4 ± 9.3 years, 24.3 ± 2.1 kg/m²) participated in the 60-day head-down tilt bed rest (AGBRESA) study. They were assigned to three groups, 30 min/day continuous, or 6(5 min intermittent short-arm centrifugation, or a control group. We assessed autonomic cardiovascular control in the supine position and in 5 minutes 80° head-up tilt position before and immediately after bed rest. We computed heart rate variability (HRV) in the time (rmssd) and frequency domain, blood pressure variability, and baroreflex sensitivity (BRS). RR interval corrected rmssd was reduced supine (p = 0.0358) and during HUT (p = 0.0161). Heart rate variability in the high-frequency band (hf-RRI; p = 0.0004) and BRS (p < 0.0001) decreased, whereas blood pressure variability in the low-frequency band (lf-SBP, p = 0.0008) increased following bedrest in all groups. We did not detect significant interactions between bedrest and interventions. We conclude that up to daily 30 min of artificial gravity on a short-arm centrifuge with 1Gz at the center of mass do not suffice to prevent changes in autonomic cardiovascular control following 60-day of 6° head-down tilt bed rest

Item URL in elib:https://elib.dlr.de/199810/
Document Type:Article
Title:Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Hönemann, J.Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany and Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care, University of Cologne, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Möstl, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diedrich, A.Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TNUNSPECIFIEDUNSPECIFIED
Mulder, E.UNSPECIFIEDhttps://orcid.org/0000-0003-1200-5792UNSPECIFIED
Frett, T.german aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyhttps://orcid.org/0000-0002-5572-1177UNSPECIFIED
Petrat, G.UNSPECIFIEDhttps://orcid.org/0000-0001-5725-8908UNSPECIFIED
Pustowalow, W.UNSPECIFIEDhttps://orcid.org/0000-0001-7534-6493UNSPECIFIED
Arz, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitz, M.T.Institute of Medical Biometry, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Bonn, GermanyUNSPECIFIEDUNSPECIFIED
Heusser, K.UNSPECIFIEDhttps://orcid.org/0000-0002-2571-5585UNSPECIFIED
Lee, S.M.C.Wyle Laboratories, Life Sciences and Systems Division, Houston, TX, United StatesUNSPECIFIEDUNSPECIFIED
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Tank, J.UNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Hoffmann, F.Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany and Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care, University of Cologne, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Date:23 October 2023
Journal or Publication Title:Frontiers in cardiovascular medicine
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:10
DOI:10.3389/fcvm.2023.1250727
Page Range:p. 1250727
Publisher:Frontiers Media S.A.
ISSN:2297-055X
Status:Published
Keywords:artificial gravity; autonomic nervous system; bed rest; cardiovascular deconditioning; tilt table test
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:05 Dec 2023 15:04
Last Modified:07 Dec 2023 14:12

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