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Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine

Jordan, J. and Limper, U. and Tank, J. (2022) Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine. Neurological Sciences, 43 (5), pp. 3039-3051. Springer Nature. doi: 10.1007/s10072-022-05963-7. ISSN 1590-1874.

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Official URL: https://doi.org/10.1007/s10072-022-05963-7

Abstract

Background: The harsh environmental conditions during space travel, particularly weightlessness, impose a major burden on the human body including the cardiovascular system. Given its importance in adjusting the cardiovascular system to environmental challenges, the autonomic nervous system has been in the focus of scientists and clinicians involved in human space flight. This review provides an overview on human autonomic research under real and simulated space conditions with a focus on orthostatic intolerance. Methods: The authors conducted a targeted literature search using Pubmed. Results: Overall, 120 articles were identified and included in the review. Conclusions: Postflight orthostatic intolerance is commonly observed in astronauts and could pose major risks when landing on another celestial body. The phenomenon likely results from changes in volume status and adaptation of the autonomic nervous system to weightlessness. Over the years, various non-pharmacological and pharmacological countermeasures have been investigated. In addition to enabling safe human space flight, this research may have implications for patients with disorders affecting cardiovascular autonomic control on Earth.

Item URL in elib:https://elib.dlr.de/190296/
Document Type:Article
Title:Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Jordan, J.UNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Limper, U.UNSPECIFIEDhttps://orcid.org/0000-0001-9927-4180UNSPECIFIED
Tank, J.UNSPECIFIEDhttps://orcid.org/0000-0002-5672-1187UNSPECIFIED
Date:23 February 2022
Journal or Publication Title:Neurological Sciences
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:43
DOI:10.1007/s10072-022-05963-7
Page Range:pp. 3039-3051
Publisher:Springer Nature
ISSN:1590-1874
Status:Published
Keywords:Autonomic nervous system; Baroreflex; Cardiovascular reflexes; Orthostatic hypotension; Orthostatic tolerance; Space flight
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - CardioBrain
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Schrage, Larissa
Deposited On:22 Nov 2022 11:23
Last Modified:28 Jun 2023 11:21

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