Jordan, J. and Limper, U. and Tank, J. (2022) Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine. Neurological Sciences, 43 (5), pp. 3039-3051. Springer Nature. doi: 10.1007/s10072-022-05963-7. ISSN 1590-1874.
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Official URL: https://doi.org/10.1007/s10072-022-05963-7
Abstract
Background: The harsh environmental conditions during space travel, particularly weightlessness, impose a major burden on the human body including the cardiovascular system. Given its importance in adjusting the cardiovascular system to environmental challenges, the autonomic nervous system has been in the focus of scientists and clinicians involved in human space flight. This review provides an overview on human autonomic research under real and simulated space conditions with a focus on orthostatic intolerance. Methods: The authors conducted a targeted literature search using Pubmed. Results: Overall, 120 articles were identified and included in the review. Conclusions: Postflight orthostatic intolerance is commonly observed in astronauts and could pose major risks when landing on another celestial body. The phenomenon likely results from changes in volume status and adaptation of the autonomic nervous system to weightlessness. Over the years, various non-pharmacological and pharmacological countermeasures have been investigated. In addition to enabling safe human space flight, this research may have implications for patients with disorders affecting cardiovascular autonomic control on Earth.
Item URL in elib: | https://elib.dlr.de/190296/ | ||||||||||||||||
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Document Type: | Article | ||||||||||||||||
Title: | Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine | ||||||||||||||||
Authors: |
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Date: | 23 February 2022 | ||||||||||||||||
Journal or Publication Title: | Neurological Sciences | ||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||
Open Access: | Yes | ||||||||||||||||
Gold Open Access: | No | ||||||||||||||||
In SCOPUS: | Yes | ||||||||||||||||
In ISI Web of Science: | Yes | ||||||||||||||||
Volume: | 43 | ||||||||||||||||
DOI: | 10.1007/s10072-022-05963-7 | ||||||||||||||||
Page Range: | pp. 3039-3051 | ||||||||||||||||
Publisher: | Springer Nature | ||||||||||||||||
ISSN: | 1590-1874 | ||||||||||||||||
Status: | Published | ||||||||||||||||
Keywords: | Autonomic nervous system; Baroreflex; Cardiovascular reflexes; Orthostatic hypotension; Orthostatic tolerance; Space flight | ||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||
HGF - Program: | Space | ||||||||||||||||
HGF - Program Themes: | Research under Space Conditions | ||||||||||||||||
DLR - Research area: | Raumfahrt | ||||||||||||||||
DLR - Program: | R FR - Research under Space Conditions | ||||||||||||||||
DLR - Research theme (Project): | R - CardioBrain | ||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine Institute of Aerospace Medicine > Leitungsbereich ME Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace | ||||||||||||||||
Deposited By: | Schrage, Larissa | ||||||||||||||||
Deposited On: | 22 Nov 2022 11:23 | ||||||||||||||||
Last Modified: | 28 Jun 2023 11:21 |
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