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Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA study

Clément, G. and Rittweger, J. and Nitsche, A. and Doering, W. and Frings-Meuthen, P. and Hand, O. and Frett, T. and Noppe, A. and Paulke, F. and Lecheler, L. and Jordan, J. and Stern, C. and Mulder, E. (2022) Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA study. Frontiers in Physiology, 13, p. 976926. Frontiers Media S.A. doi: 10.3389/fphys.2022.976926. ISSN 1664-042X.

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Official URL: https://doi.org/10.3389/fphys.2022.976926

Abstract

A comprehensive strategy is required to mitigate risks to astronauts' health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gravity (AG) by centrifugation simultaneously affects all physiological systems, AG could mitigate the effects of weightlessness in multiple systems. In 2019, NASA and the German Aerospace Center conducted a 60-days Artificial Gravity Bed Rest Study with the European Space Agency (AGBRESA). The objectives of this study were to 1) determine if 30 min of AG daily is protective during head down bed rest, and 2) compare the protective effects of a single daily bout (30 min) of AG versus multiple daily bouts (6 × 5 min) of AG (1 Gz at the center of mass) on physiological functions that are affected by weightlessness and by head-down tilt bed rest. The AGBRESA study involved a comprehensive suite of standard and innovative technologies to characterize changes in a broad spectrum of physiological systems. The current article is intended to provide a detailed overview of the methods used during AGBRESA.

Item URL in elib:https://elib.dlr.de/190283/
Document Type:Article
Title:Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA study
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Clément, G.KBR, Houston, TX, United StatesUNSPECIFIED
Rittweger, J.Muscle and Bone Metabolism Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Joern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Nitsche, A.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Doering, W.German Aerospace Center (DLR), Institute of Aerospace Medicine, Biomedical Science Support Center, Cologne, GermanyUNSPECIFIED
Frings-Meuthen, P.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Hand, O.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Frett, T.DLR, Institut für Luft- und Raumfahrtmedizin, Abteilung BIOUNSPECIFIED
Noppe, A.Institute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyUNSPECIFIED
Paulke, F.Study Team, DLR, Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Lecheler, L.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany and Lehrstuhl für Luft- und Raumfahrtmedizin, Universität zu Köln; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Stern, C.Clinical Aerospace Medicine Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; claudia.stern (at) dlr.deUNSPECIFIED
Mulder, E.Institut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt (DLR), Köln,UNSPECIFIED
Date:8 September 2022
Journal or Publication Title:Frontiers in Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:13
DOI:10.3389/fphys.2022.976926
Page Range:p. 976926
Publisher:Frontiers Media S.A
ISSN:1664-042X
Status:Published
Keywords:analogs; artificial gravity; bed rest; countermeasures; weightlessness
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Human performance under altered gravity conditions
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Office of Management and Budget
Institute of Aerospace Medicine > Clinical Aerospace Medicine
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Schrage, Larissa
Deposited On:22 Nov 2022 10:44
Last Modified:22 Nov 2022 10:44

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