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Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons

Kohler, Matthias and Bengtsson, Fredrik and Stratmann, Philipp and Röhrbein, Florian and Knoll, Alois and Albu-Schäffer, Alin Olimpiu and Jörntell, Henrik (2022) Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons. iScience, 25 (4). Elsevier. doi: 10.1016/j.isci.2022.104083. ISSN 2589-0042.

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Official URL: https://www.sciencedirect.com/science/article/pii/S2589004222003534


The spinal cord is engaged in all forms of motor performance but its functions are far from understood. Because network connectivity defines function, we explored the connectivity for muscular, tendon and tactile sensory inputs among a wide population of spinal interneurons in the lower cervical segments. Using low noise intracellular whole cell recordings in the decerebrated, non-anesthetized cat in vivo, we could define mono-, di-, trisynaptic inputs as well as the weights of each input. Whereas each neuron had a highly specific input, and each indirect input could moreover be explained by inputs in other recorded neurons, we unexpectedly also found the input connectivity of the spinal interneuron population to form a continuum. Our data hence contrasts with the currently widespread notion of distinct classes of interneurons. We argue that this suggested diversified physiological connectivity, which likely requires a major component of circuitry learning, implies a more flexible functionality.

Item URL in elib:https://elib.dlr.de/185888/
Document Type:Article
Title:Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Kohler, MatthiasTechnische Universität MünchenUNSPECIFIEDUNSPECIFIED
Bengtsson, FredrikLund University, SwedenUNSPECIFIEDUNSPECIFIED
Stratmann, PhilippTechnische Universität Münchenhttps://orcid.org/0000-0001-6791-9159UNSPECIFIED
Röhrbein, FlorianChemnitz University of TechnologyUNSPECIFIEDUNSPECIFIED
Knoll, AloisTechnische Universität MünchenUNSPECIFIEDUNSPECIFIED
Albu-Schäffer, Alin OlimpiuUNSPECIFIEDhttps://orcid.org/0000-0001-5343-9074142115896
Jörntell, HenrikLund University, SwedenUNSPECIFIEDUNSPECIFIED
Date:15 April 2022
Journal or Publication Title:iScience
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Keywords:Behavioral Neuroscience; Biological Cciences; Cellular Neuroscience, Spinal Interneurons, Robotics
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Robotics
DLR - Research area:Raumfahrt
DLR - Program:R RO - Robotics
DLR - Research theme (Project):R - On-Orbit Servicing [RO], R - Basic Technologies [RO]
Location: Oberpfaffenhofen
Institutes and Institutions:Institute of Robotics and Mechatronics (since 2013)
Deposited By: Beinhofer, Gabriele
Deposited On:02 May 2022 11:27
Last Modified:11 Sep 2023 13:24

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