Kohler, Matthias und Bengtsson, Fredrik und Stratmann, Philipp und Röhrbein, Florian und Knoll, Alois und Albu-Schäffer, Alin Olimpiu und Jörntell, Henrik (2022) Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons. iScience, 25 (4). Elsevier. doi: 10.1016/j.isci.2022.104083. ISSN 2589-0042.
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Offizielle URL: https://www.sciencedirect.com/science/article/pii/S2589004222003534
Kurzfassung
The spinal cord is engaged in all forms of motor performance but its functions are far from understood. Because network connectivity defines function, we explored the connectivity for muscular, tendon and tactile sensory inputs among a wide population of spinal interneurons in the lower cervical segments. Using low noise intracellular whole cell recordings in the decerebrated, non-anesthetized cat in vivo, we could define mono-, di-, trisynaptic inputs as well as the weights of each input. Whereas each neuron had a highly specific input, and each indirect input could moreover be explained by inputs in other recorded neurons, we unexpectedly also found the input connectivity of the spinal interneuron population to form a continuum. Our data hence contrasts with the currently widespread notion of distinct classes of interneurons. We argue that this suggested diversified physiological connectivity, which likely requires a major component of circuitry learning, implies a more flexible functionality.
elib-URL des Eintrags: | https://elib.dlr.de/185888/ | ||||||||||||||||||||||||||||||||
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Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||||||||||||||
Titel: | Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons | ||||||||||||||||||||||||||||||||
Autoren: |
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Datum: | 15 April 2022 | ||||||||||||||||||||||||||||||||
Erschienen in: | iScience | ||||||||||||||||||||||||||||||||
Referierte Publikation: | Ja | ||||||||||||||||||||||||||||||||
Open Access: | Ja | ||||||||||||||||||||||||||||||||
Gold Open Access: | Ja | ||||||||||||||||||||||||||||||||
In SCOPUS: | Ja | ||||||||||||||||||||||||||||||||
In ISI Web of Science: | Ja | ||||||||||||||||||||||||||||||||
Band: | 25 | ||||||||||||||||||||||||||||||||
DOI: | 10.1016/j.isci.2022.104083 | ||||||||||||||||||||||||||||||||
Verlag: | Elsevier | ||||||||||||||||||||||||||||||||
ISSN: | 2589-0042 | ||||||||||||||||||||||||||||||||
Status: | veröffentlicht | ||||||||||||||||||||||||||||||||
Stichwörter: | Behavioral Neuroscience; Biological Cciences; Cellular Neuroscience, Spinal Interneurons, Robotics | ||||||||||||||||||||||||||||||||
HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||||||||||||||||||||||||||
HGF - Programm: | Raumfahrt | ||||||||||||||||||||||||||||||||
HGF - Programmthema: | Robotik | ||||||||||||||||||||||||||||||||
DLR - Schwerpunkt: | Raumfahrt | ||||||||||||||||||||||||||||||||
DLR - Forschungsgebiet: | R RO - Robotik | ||||||||||||||||||||||||||||||||
DLR - Teilgebiet (Projekt, Vorhaben): | R - On-Orbit Servicing [RO], R - Basistechnologien [RO] | ||||||||||||||||||||||||||||||||
Standort: | Oberpfaffenhofen | ||||||||||||||||||||||||||||||||
Institute & Einrichtungen: | Institut für Robotik und Mechatronik (ab 2013) | ||||||||||||||||||||||||||||||||
Hinterlegt von: | Beinhofer, Gabriele | ||||||||||||||||||||||||||||||||
Hinterlegt am: | 02 Mai 2022 11:27 | ||||||||||||||||||||||||||||||||
Letzte Änderung: | 11 Sep 2023 13:24 |
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