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DNA DOUBLE STRAND BREAK REPAIR DURING HEAD-DOWN-TILT BEDREST: AGBRESA MEETS RADIATION

Diegeler, Sebastian and Hellweg, Christine E. and Schmitz, Claudia and Kronenberg, Jessica and Mulder, Edwin and Bohmeier, Maria and Schrage-Knoll, Irmtrud and Kraus, Gabriele and Huth, Elfriede and Berwanger, Carolin and Paulke, Freia Barbara and Lecheler, Leopold and Jordan, Jens (2021) DNA DOUBLE STRAND BREAK REPAIR DURING HEAD-DOWN-TILT BEDREST: AGBRESA MEETS RADIATION. COSPAR 2021, 28. Januar - 4. Februar 2021, Sydney, Australia and Virtual Event (Hybrid).

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Abstract

BACKGROUND Radiation and reduced gravity impose a major burden on health and performance during human spaceflight. While radiation increases cancer risk and limits tissue regeneration, reduced gravity predisposes to musculoskeletal and cardiovascular deconditioning. Deconditioning could conceivably limit the recovery from radiation damage. Our aim was to develop a terrestrial ex vivo model that could be utilized to study the effect of simulated reduced gravity using head-down-tilt bed-rest on repair of ionizing-radiation-induced DNA damage.

Item URL in elib:https://elib.dlr.de/141298/
Document Type:Conference or Workshop Item (Speech)
Title:DNA DOUBLE STRAND BREAK REPAIR DURING HEAD-DOWN-TILT BEDREST: AGBRESA MEETS RADIATION
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Diegeler, SebastianRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Sebastian.Diegeler (at) dlr.deUNSPECIFIED
Hellweg, Christine E.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Christine.Hellweg (at) dlr.dehttps://orcid.org/0000-0002-2223-3580
Schmitz, ClaudiaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Kronenberg, JessicaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Mulder, EdwinInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Bohmeier, MariaInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Schrage-Knoll, IrmtrudInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Kraus, GabrieleInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Huth, ElfriedeInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Berwanger, CarolinInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Paulke, Freia BarbaraInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Lecheler, LeopoldInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyUNSPECIFIED
Jordan, JensInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Jens.Jordan (at) dlr.dehttps://orcid.org/0000-0003-4518-0706
Date:29 January 2021
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Artificial Gravity Bed Rest Study, AGBRESA, DNA damage, radiation
Event Title:COSPAR 2021
Event Location:Sydney, Australia and Virtual Event (Hybrid)
Event Type:international Conference
Event Dates:28. Januar - 4. Februar 2021
Organizer:COSPAR - COMMITTEE ON SPACE RESEARCH
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Project ISS LIFE 2.0
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Office of Management and Budget
Deposited By: Kopp, Kerstin
Deposited On:12 Mar 2021 10:39
Last Modified:14 Apr 2021 15:51

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