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Biological data questions the support of the self inhibition required for pattern generation in the half center model

Kohler, Matthias and Stratmann, Philipp and Röhrbein, Florian and Knoll, Alois and Albu-Schäffer, Alin Olimpiu and Jörntell, Henrik (2020) Biological data questions the support of the self inhibition required for pattern generation in the half center model. PLoS One, pp. 1-20. Public Library of Science (PLoS). doi: 10.1371/journal.pone.0238586. ISSN 1932-6203.

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Abstract

Locomotion control in mammals has been hypothesized to be governed by a central pattern generator (CPG) located in the circuitry of the spinal cord. The most common model of the CPG is the half center model, where two pools of neurons generate alternating, oscillatory activity. In this model, the pools reciprocally inhibit each other ensuring alternating activity. There is experimental support for reciprocal inhibition. However another crucial part of the half center model is a self inhibitory mechanism which prevents the neurons of each individual pool from infinite firing. Self-inhibition is hence necessary to obtain alternating activity. But critical parts of the experimental bases for the proposed mechanisms for self-inhibition were obtained in vitro, in preparations of juvenile animals. The commonly used adaptation of spike firing does not appear to be present in adult animals in vivo. We therefore modeled several possible self inhibitory mechanisms for locomotor control. Based on currently published data, previously proposed hypotheses of the self inhibitory mechanism, necessary to support the CPG hypothesis, seems to be put into question by functional evaluation tests or by in vivo data. This opens for alternative explanations of how locomotion activity patterns in the adult mammal could be generated.

Item URL in elib:https://elib.dlr.de/137776/
Document Type:Article
Title:Biological data questions the support of the self inhibition required for pattern generation in the half center model
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Kohler, MatthiasTUMUNSPECIFIED
Stratmann, PhilippPhilipp.Stratmann (at) dlr.deUNSPECIFIED
Röhrbein, FlorianTUMUNSPECIFIED
Knoll, AloisTUMUNSPECIFIED
Albu-Schäffer, Alin OlimpiuAlin.Albu-Schaeffer (at) dlr.deUNSPECIFIED
Jörntell, HenrikLund UniversityUNSPECIFIED
Date:11 September 2020
Journal or Publication Title:PLoS One
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1371/journal.pone.0238586
Page Range:pp. 1-20
Publisher:Public Library of Science (PLoS)
ISSN:1932-6203
Status:Published
Keywords:Locomotion control
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Space System Technology
DLR - Research area:Raumfahrt
DLR - Program:R SY - Space System Technology
DLR - Research theme (Project):R - On-Orbit Servicing [SY]
Location: Oberpfaffenhofen
Institutes and Institutions:Institute of Robotics and Mechatronics (since 2013)
Deposited By: Beinhofer, Gabriele
Deposited On:24 Nov 2020 17:17
Last Modified:24 Nov 2020 17:17

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  • Biological data questions the support of the self inhibition required for pattern generation in the half center model. (deposited 24 Nov 2020 17:17) [Currently Displayed]

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