DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Tolerability of daily intermittent or continuous short-arm centrifugation during 60-day 6o head down bed rest (AGBRESA study)

Frett, Timo and Green, David Andrew and Mulder, Edwin and Noppe, Alexandra and Arz, Michael and Pustowalow, Willi and Petrat, Guido and Tegtbur, Uwe and Jordan, Jens (2020) Tolerability of daily intermittent or continuous short-arm centrifugation during 60-day 6o head down bed rest (AGBRESA study). PLoS One, 15 (9), e0239228. Public Library of Science (PLoS). doi: 10.1371/journal.pone.0239228. ISSN 1932-6203.

[img] PDF - Postprint version (accepted manuscript)

Official URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239228


Artificial gravity through short-arm centrifugation has potential as a multi-system countermeasure for deconditioning and cranial fluid shifts that may underlie ocular issues in microgravity. However, the optimal short-arm centrifugation protocol that is effective whilst remaining tolerable has yet to be determined. Given that exposure to centrifugation is associated with presyncope and syncope and in addition motion sickness an intermittent protocol has been suggested to be more tolerable. Therefore, we assessed cardiovascular loading and subjective tolerability of daily short arm centrifugation with either an intermittent or a continuous protocol during long-term head-down bed rest as model for microgravity exposure in a mixed sex cohort. During the Artificial Gravity Bed Rest with European Space Agency (AGBRESA) 60 day 6° head down tilt bed rest study we compared the tolerability of daily +1 Gz exposure at the center of mass centrifugation, either performed continuously for 30 minutes, or intermittedly (6 x 5 minutes). Heart rate and blood pressure were assessed daily during centrifugation along with post motion sickness scoring and rate of perceived exertion. During bed rest, 16 subjects (6 women, 10 men), underwent 960 centrifuge runs in total. Ten centrifuge runs had to be terminated prematurely, 8 continuous runs and 2 intermittent runs, mostly due to pre-syncopal symptoms and not motion sickness. All subjects were, however, able to resume centrifuge training on subsequent days. We conclude that both continuous and intermittent short-arm centrifugation protocols providing artificial gravity equivalent to +1 Gz at the center of mass is tolerable in terms of cardiovascular loading and motion sickness during long-term head down tilt bed rest. However, intermittent centrifugation appears marginally better tolerated, albeit differences appear minor.

Item URL in elib:https://elib.dlr.de/136486/
Document Type:Article
Title:Tolerability of daily intermittent or continuous short-arm centrifugation during 60-day 6o head down bed rest (AGBRESA study)
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Frett, TimoUNSPECIFIEDhttps://orcid.org/0000-0002-5572-1177UNSPECIFIED
Green, David AndrewEuropean Astronaut CenterUNSPECIFIEDUNSPECIFIED
Mulder, EdwinGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Arz, MichaelInstitute of Aerospace Medicine, German Aerospace Center (DLR), Linder Hoehe, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Petrat, GuidoGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Biomedical Science Support Center, Linder Hoehe, 51147 Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Tegtbur, UweInstitute of Sports Medicine, Hannover Medical School, 30625 Hannover, GermanyUNSPECIFIEDUNSPECIFIED
Jordan, JensUNSPECIFIEDhttps://orcid.org/0000-0003-4518-0706UNSPECIFIED
Date:September 2020
Journal or Publication Title:PLoS One
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:e0239228
Publisher:Public Library of Science (PLoS)
Keywords:Artificial Gravity, Space flight, Centrifugation, AGBRESA
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Operationelle Forschung Kurzarmzentrifuge (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Institute of Aerospace Medicine > Gravitational Biology
Institute of Aerospace Medicine > Muscle and Bone Metabolism
Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Office of Management and Budget
Deposited By: Frett, Timo
Deposited On:07 Oct 2020 11:41
Last Modified:24 Oct 2023 14:36

Repository Staff Only: item control page

Help & Contact
electronic library is running on EPrints 3.3.12
Website and database design: Copyright © German Aerospace Center (DLR). All rights reserved.