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Scaling Our World View: How Monoamines Can Put Context Into Brain Circuitry

Stratmann, Philipp and Albu-Schäffer, Alin and Jörntell, Henrik (2018) Scaling Our World View: How Monoamines Can Put Context Into Brain Circuitry. Frontiers in Cellular Neuroscience, 12. Frontiers Media S.A.. doi: 10.3389/fncel.2018.00506. ISSN 1662-5102.

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Official URL: https://www.frontiersin.org/articles/10.3389/fncel.2018.00506/


Monoamines are presumed to be diffuse metabotropic neuromodulators of the topographically and temporally precise ionotropic circuitry which dominates CNS functions. Their malfunction is strongly implicated in motor and cognitive disorders, but their function in behavioral and cognitive processing is scarcely understood. In this paper, the principles of such a monoaminergic function are conceptualized for locomotor control. We find that the serotonergic system in the ventral spinal cord scales ionotropic signals and shows topographic order that agrees with differential gain modulation of ionotropic subcircuits. Whereas the subcircuits can collectively signal predictive models of the world based on life-long learning, their differential scaling continuously adjusts these models to changing mechanical contexts based on sensory input on a fast time scale of a few 100 ms. The control theory of biomimetic robots demonstrates that this precision scaling is an effective and resource-efficient solution to adapt the activation of individual muscle groups during locomotion to changing conditions such as ground compliance and carried load. Although it is not unconceivable that spinal ionotropic circuitry could achieve scaling by itself, neurophysiological findings emphasize that this is a unique functionality of metabotropic effects since recent recordings in sensorimotor circuitry conflict with mechanisms proposed for ionotropic scaling in other CNS areas. We substantiate that precision scaling of ionotropic subcircuits is a main functional principle for many monoaminergic projections throughout the CNS, implying that the monoaminergic circuitry forms a network within the network composed of the ionotropic circuitry. Thereby, we provide an early-level interpretation of the mechanisms of psychopharmacological drugs that interfere with the monoaminergic systems.

Item URL in elib:https://elib.dlr.de/125493/
Document Type:Article
Title:Scaling Our World View: How Monoamines Can Put Context Into Brain Circuitry
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Stratmann, PhilippUNSPECIFIEDhttps://orcid.org/0000-0001-6791-9159UNSPECIFIED
Albu-Schäffer, AlinUNSPECIFIEDhttps://orcid.org/0000-0001-5343-9074UNSPECIFIED
Jörntell, HenrikLund University, SwedenUNSPECIFIEDUNSPECIFIED
Date:20 December 2018
Journal or Publication Title:Frontiers in Cellular Neuroscience
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Publisher:Frontiers Media S.A.
Keywords:monoamine neurotransmitter disorders, motor control, motor learning, neuromodulation, principal component analysis, raphe nuclei, serotonin, spinal cord
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Space System Technology
DLR - Research area:Raumfahrt
DLR - Program:R SY - Space System Technology
DLR - Research theme (Project):R - Terrestrial Assistance Robotics (old), R - Vorhaben Weiterentwicklung Robotik - Mechatronik und Dynamik (old)
Location: Oberpfaffenhofen
Institutes and Institutions:Institute of Robotics and Mechatronics (since 2013)
Deposited By: Stratmann, Philipp
Deposited On:21 Dec 2018 10:49
Last Modified:30 Jan 2024 11:56

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