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Microbial Response to Spaceflight Conditions

Moeller, R. (2017) Microbial Response to Spaceflight Conditions. EAPS Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Department for Molecular Biology, Massachusetts General Hospital (MGH) - Seminar, October 31, 2017, Boston, MA, USA.

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Space radiation, including Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE), represents a major hazard for biological systems beyond Earth. Spores of Bacillus subtilis have been shown to be suitable dosimeters for probing extreme terrestrial and extraterrestrial environmental conditions in astrobiological and environmental studies. During dormancy spores are metabolically inactive; thus substantial DNA, protein, tRNA and ribosome damage can accumulate while the spores are incapable of repairing and/or degrading damaged DNA and proteins. We used different genotypes of B. subtilis to study the effects of extraterrestrial conditions in both space and ground-based experiments. Spore survival was strongly dependent on the functionality of all of the structural components, with small acid-soluble spore proteins, coat layers, and dipicolinic acid (DPA) and the interaction of several DNA repair mechanisms. I will present results from physiological and genetic studies regarding spore resistance to spaceflight conditions as well as data from the transcriptome analyses of germinating B. subtilis spores. Our ultimate goal is to obtain a complete model describing spore persistence and longevity in high radiation-exposed environments, with implications for future life detection missions and human spaceflight.

Item URL in elib:https://elib.dlr.de/118103/
Document Type:Conference or Workshop Item (Speech)
Title:Microbial Response to Spaceflight Conditions
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Moeller, R.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (dlr), Cologne, Germany; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In ISI Web of Science:No
Keywords:Astrobiology, Microbiology, spaceflight conditions
Event Title:EAPS Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Department for Molecular Biology, Massachusetts General Hospital (MGH) - Seminar
Event Location:Boston, MA, USA
Event Type:Other
Event Dates:October 31, 2017
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:11 Jan 2018 13:44
Last Modified:31 Jul 2019 20:15

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