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Simulating Parabolic Flight like g-Profiles on Ground - A Combination of Centrifuge and Clinostat

Brungs, Sonja and Petrat, Guido and von der Wiesche, Melanie and Anken, Ralf and Kolanus, Waldemar and Hemmersbach, Ruth (2015) Simulating Parabolic Flight like g-Profiles on Ground - A Combination of Centrifuge and Clinostat. Microgravity Science and Technology, pp. 1-5. Springer. DOI: 10.1007/s12217-015-9458-5 ISSN 0938-0108

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1007/s12217-015-9458-5

Abstract

Clinostats and centrifuges are widely used to create simulated microgravity or hypergravity, respectively, in order to study the impact of gravity on biosystems. Here, we used a clinostat and a centrifuge in alternating modes of operation in order to create a simulated parabolic flight like g-profile. To our knowledge, it is the first time that both devices were run in connection. In order to test the method, we investigated the production of reactive oxygen species of immune cells (macrophages) during oxidative burst in an on-line kinetic approach, which has been extensively studied under real (parabolic flight) and simulated microgravity (clinostat) as well as under hypergravity conditions (centrifuge). Our results indicate that clinostat and centrifuge can be operated in an alternating way to simulate the repetitive changes of gravity during parabolic flight. Although the switch from one gravity level to the other could not be carried out as quickly as it takes place during actual parabolic flight due to technical and operational reasons, it can be concluded that running experiments in a clinostat aboard a centrifuge on ground are suitable for studying gravity-related phenomena.

Item URL in elib:https://elib.dlr.de/102756/
Document Type:Article
Title:Simulating Parabolic Flight like g-Profiles on Ground - A Combination of Centrifuge and Clinostat
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Brungs, SonjaGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Petrat, GuidoGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Biomedical Science Support Center, Cologne, GermanyUNSPECIFIED
von der Wiesche, MelanieGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Anken, RalfGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Kolanus, WaldemarLife and Medical Sciences (LIMES) Institute, University of Bonn, Karlrobert-Kreiten-Straße 13, 53115 Bonn, GermanyUNSPECIFIED
Hemmersbach, RuthGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Date:24 September 2015
Journal or Publication Title:Microgravity Science and Technology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1007/s12217-015-9458-5
Page Range:pp. 1-5
Publisher:Springer
ISSN:0938-0108
Status:Published
Keywords:Hypergravity, Microgravity, Centrifuge, Clinostat, Parabolic flight
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Biomedical Research
Institute of Aerospace Medicine > Office of Management and Budget
Deposited By: Hoven, Claudio
Deposited On:03 Feb 2016 09:50
Last Modified:10 May 2016 23:44

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