Brungs, Sonja und Petrat, Guido und von der Wiesche, Melanie und Anken, Ralf und Kolanus, Waldemar und Hemmersbach, Ruth (2015) Simulating Parabolic Flight like g-Profiles on Ground - A Combination of Centrifuge and Clinostat. Microgravity Science and Technology, Seiten 1-5. Springer. doi: 10.1007/s12217-015-9458-5. ISSN 0938-0108.
Dieses Archiv kann nicht den Volltext zur Verfügung stellen.
Offizielle URL: http://dx.doi.org/10.1007/s12217-015-9458-5
Kurzfassung
Clinostats and centrifuges are widely used to create simulated microgravity or hypergravity, respectively, in order to study the impact of gravity on biosystems. Here, we used a clinostat and a centrifuge in alternating modes of operation in order to create a simulated parabolic flight like g-profile. To our knowledge, it is the first time that both devices were run in connection. In order to test the method, we investigated the production of reactive oxygen species of immune cells (macrophages) during oxidative burst in an on-line kinetic approach, which has been extensively studied under real (parabolic flight) and simulated microgravity (clinostat) as well as under hypergravity conditions (centrifuge). Our results indicate that clinostat and centrifuge can be operated in an alternating way to simulate the repetitive changes of gravity during parabolic flight. Although the switch from one gravity level to the other could not be carried out as quickly as it takes place during actual parabolic flight due to technical and operational reasons, it can be concluded that running experiments in a clinostat aboard a centrifuge on ground are suitable for studying gravity-related phenomena.
elib-URL des Eintrags: | https://elib.dlr.de/102756/ | ||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||||||||||
Titel: | Simulating Parabolic Flight like g-Profiles on Ground - A Combination of Centrifuge and Clinostat | ||||||||||||||||||||||||||||
Autoren: |
| ||||||||||||||||||||||||||||
Datum: | 24 September 2015 | ||||||||||||||||||||||||||||
Erschienen in: | Microgravity Science and Technology | ||||||||||||||||||||||||||||
Referierte Publikation: | Ja | ||||||||||||||||||||||||||||
Open Access: | Nein | ||||||||||||||||||||||||||||
Gold Open Access: | Nein | ||||||||||||||||||||||||||||
In SCOPUS: | Ja | ||||||||||||||||||||||||||||
In ISI Web of Science: | Ja | ||||||||||||||||||||||||||||
DOI: | 10.1007/s12217-015-9458-5 | ||||||||||||||||||||||||||||
Seitenbereich: | Seiten 1-5 | ||||||||||||||||||||||||||||
Verlag: | Springer | ||||||||||||||||||||||||||||
ISSN: | 0938-0108 | ||||||||||||||||||||||||||||
Status: | veröffentlicht | ||||||||||||||||||||||||||||
Stichwörter: | Hypergravity, Microgravity, Centrifuge, Clinostat, Parabolic flight | ||||||||||||||||||||||||||||
HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||||||||||||||||||||||
HGF - Programm: | Raumfahrt | ||||||||||||||||||||||||||||
HGF - Programmthema: | Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||
DLR - Schwerpunkt: | Raumfahrt | ||||||||||||||||||||||||||||
DLR - Forschungsgebiet: | R FR - Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||
DLR - Teilgebiet (Projekt, Vorhaben): | R - Vorhaben Biowissenschaftliche Nutzerunterstützung (alt) | ||||||||||||||||||||||||||||
Standort: | Köln-Porz | ||||||||||||||||||||||||||||
Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin > Biomedizinische Forschung Institut für Luft- und Raumfahrtmedizin > Zentrale Aufgaben | ||||||||||||||||||||||||||||
Hinterlegt von: | Hoven, Claudio | ||||||||||||||||||||||||||||
Hinterlegt am: | 03 Feb 2016 09:50 | ||||||||||||||||||||||||||||
Letzte Änderung: | 03 Nov 2023 08:14 |
Nur für Mitarbeiter des Archivs: Kontrollseite des Eintrags