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Microbial Response to Spaceflight Conditions

Moeller, R. (2017) Microbial Response to Spaceflight Conditions. EAPS Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Department for Molecular Biology, Massachusetts General Hospital (MGH) - Seminar, 2017-10-31, Boston, MA, USA.

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Kurzfassung

Space radiation, including Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE), represents a major hazard for biological systems beyond Earth. Spores of Bacillus subtilis have been shown to be suitable dosimeters for probing extreme terrestrial and extraterrestrial environmental conditions in astrobiological and environmental studies. During dormancy spores are metabolically inactive; thus substantial DNA, protein, tRNA and ribosome damage can accumulate while the spores are incapable of repairing and/or degrading damaged DNA and proteins. We used different genotypes of B. subtilis to study the effects of extraterrestrial conditions in both space and ground-based experiments. Spore survival was strongly dependent on the functionality of all of the structural components, with small acid-soluble spore proteins, coat layers, and dipicolinic acid (DPA) and the interaction of several DNA repair mechanisms. I will present results from physiological and genetic studies regarding spore resistance to spaceflight conditions as well as data from the transcriptome analyses of germinating B. subtilis spores. Our ultimate goal is to obtain a complete model describing spore persistence and longevity in high radiation-exposed environments, with implications for future life detection missions and human spaceflight.

elib-URL des Eintrags:https://elib.dlr.de/118103/
Dokumentart:Konferenzbeitrag (Vortrag)
Titel:Microbial Response to Spaceflight Conditions
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Moeller, R.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (dlr), Cologne, Germany; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676NICHT SPEZIFIZIERT
Datum:2017
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:Astrobiology, Microbiology, spaceflight conditions
Veranstaltungstitel:EAPS Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Department for Molecular Biology, Massachusetts General Hospital (MGH) - Seminar
Veranstaltungsort:Boston, MA, USA
Veranstaltungsart:Andere
Veranstaltungsdatum:31 Oktober 2017
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Strahlenbiologie (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:11 Jan 2018 13:44
Letzte Änderung:24 Apr 2024 20:22

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