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A 1D pulse wave propagation model of the hemodynamics of calf muscle pump function

Keijsers, J.M.T. and Leguy, C.A.D. and Huberts, W. and Narracott, A.J. and Rittweger, J. and van de Vosse, F.N. (2015) A 1D pulse wave propagation model of the hemodynamics of calf muscle pump function. International Journal for Numerical Methods in Biomedical Engineering, 31 (7), e02714. Wiley. DOI: 10.1002/cnm.2714 ISSN 2040-7939

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Abstract

The calf muscle pump is a mechanism which increases venous return and thereby compensates for the fluid shift towards the lower body during standing. During a muscle contraction, the embedded deep veins collapse and venous return increases. In the subsequent relaxation phase, muscle perfusion increases due to increased perfusion pressure, as the proximal venous valves temporarily reduce the distal venous pressure (shielding). The superficial and deep veins are connected via perforators, which contain valves allowing flow in the superficial-to-deep direction. The aim of this study is to investigate and quantify the physiological mechanisms of the calf muscle pump, including the effect of venous valves, hydrostatic pressure, and the superficial venous system. Using a one-dimensional pulse wave propagation model, a muscle contraction is simulated by increasing the extravascular pressure in the deep venous segments. The hemodynamics are studied in three different configurations: a single artery-vein configuration with and without valves and a more detailed configuration including a superficial vein. Proximal venous valves increase effective venous return by 53% by preventing reflux. Furthermore, the proximal valves shielding function increases perfusion following contraction. Finally, the superficial system aids in maintaining the perfusion during the contraction phase and reduces the refilling time by 37%.

Item URL in elib:https://elib.dlr.de/98326/
Document Type:Article
Title:A 1D pulse wave propagation model of the hemodynamics of calf muscle pump function
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Keijsers, J.M.T.Institute of Aerospace Medicine, German Aerospace CenterUNSPECIFIED
Leguy, C.A.D.Institute of Aerospace Medicine, German Aerospace CenterUNSPECIFIED
Huberts, W.Department of Biomedical Engineering, Eindhoven University of TechnologyUNSPECIFIED
Narracott, A.J.Medical Physics Group, Department of Cardiovascular Science, University of SheffieldUNSPECIFIED
Rittweger, J.Institute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
van de Vosse, F.N.Department of Biomedical Engineering, Eindhoven University of Technology,UNSPECIFIED
Date:2015
Journal or Publication Title:International Journal for Numerical Methods in Biomedical Engineering
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:31
DOI :10.1002/cnm.2714
Page Range:e02714
Publisher:Wiley
ISSN:2040-7939
Status:Published
Keywords:muscle pump; collapsible vein; gravity; 1D pulse wave propagation; venous valves; orthostatic intolerance
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:29 Sep 2015 11:16
Last Modified:08 Mar 2018 18:38

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