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Influence of bed rest on plasma galanin and adrenomedullin at presyncope.

O'Shea, D. and Lackner, H.K. and Rössler, A. and Green, D.A. and Gauger, P. and Mulder, E. and Tamma, G. and Hinghofer-Szalkay, H. and Valenti, G. and Goswami, N. (2015) Influence of bed rest on plasma galanin and adrenomedullin at presyncope. European Journal of Clinical Investigation, 45 (7), pp. 679-685. Wiley. DOI: 10.1111/eci.12455 ISSN 0014-2972

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Abstract

BACKGROUND: The role of hormones in reduced orthostatic tolerance following long-term immobilization remains uncertain. We have previously shown that plasma concentrations of adrenomedullin and galanin, two peptides with vasodepressor properties, rise significantly during orthostatic challenge. We tested the hypothesis that bedrest immobilization increases the rise in adrenomedullin and galanin during orthostatic challenge leading to presyncope. MATERIALS AND METHODS: We measured baseline (supine), presyncope and recovery (10 min postpresyncope, supine) levels of adrenomedullin and galanin in 8 healthy men, before and after 21 days of -6° head-down bed rest (HDBR). Presyncope was elicited using a combined head-up tilt and graded lower body negative pressure protocol. Orthostatic tolerance was defined as the time taken from the commencement of head-up tilt to the development of presyncope. RESULTS: Orthostatic tolerance time after HDBR reduced by 8·36 ± 5·39 min (P = 0·0032). HDBR increased plasma adrenomedullin concentration to orthostatic challenge (P = 0·0367). Compared to pre-HDBR, a significant rise in post-HDBR presyncopal (P < 0·001) and recovery adrenomedullin concentration (P < 0·01) was demonstrated. In contrast, we observed no change in pre- and post-HDBR galanin levels to orthostatic challenge. CONCLUSIONS: Bedrest immobilization appears to affect adrenomedullin levels in that greater increases in adrenomedullin occur at presyncope following bedrest immobilization. Due to its peripheral vasculature hypotensive effect, the greater levels of adrenomedullin at presyncope following bedrest immobilization may have contributed to the reduced orthostatic capacity postbedrest.

Item URL in elib:https://elib.dlr.de/98324/
Document Type:Article
Title:Influence of bed rest on plasma galanin and adrenomedullin at presyncope.
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
O'Shea, D.Gravitational Physiology and Medicine research unit, Institute of Physiology, Medical University of Graz, Graz, Austria and Centre of Human & Aerospace Physiological Sciences, King's College London, London, UK.UNSPECIFIED
Lackner, H.K.Gravitational Physiology and Medicine research unit, Institute of Physiology, Medical University of Graz, Graz, Austria.UNSPECIFIED
Rössler, A.Gravitational Physiology and Medicine research unit, Institute of Physiology, Medical University of Graz, Graz, Austria.UNSPECIFIED
Green, D.A.Centre of Human & Aerospace Physiological Sciences, King's College London, London, UK.UNSPECIFIED
Gauger, P.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Mulder, E.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Tamma, G.Department of Biosciences, Biotechnologies and Biopharmaceutics University of Bari, Bari, Italy.UNSPECIFIED
Hinghofer-Szalkay, H.Gravitational Physiology and Medicine research unit, Institute of Physiology, Medical University of Graz, Graz, Austria.UNSPECIFIED
Valenti, G.Department of Biosciences, Biotechnologies and Biopharmaceutics University of Bari, Bari, Italy.UNSPECIFIED
Goswami, N.Gravitational Physiology and Medicine research unit, Institute of Physiology, Medical University of Graz, Graz, Austria.UNSPECIFIED
Date:July 2015
Journal or Publication Title:European Journal of Clinical Investigation
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:45
DOI :10.1111/eci.12455
Page Range:pp. 679-685
Editors:
EditorsEmail
Ioannidis, John P.A.UNSPECIFIED
Publisher:Wiley
ISSN:0014-2972
Status:Published
Keywords:Head-up tilt; lower body negative pressure; orthostatic challenge; syncope
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:29 Sep 2015 11:04
Last Modified:06 Sep 2019 15:16

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