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Agreement Between 24-Hour Salt Ingestion and Sodium Excretion in a Controlled Environment

Lerchl, Kathrin and Rakova, Natalia and Dahlmann, Anke and Rauh, Manfred and Goller, U. and Basner, Mathias and Dinges, David F. and Beck, Luis and Agureev, A. and Larina, Irina and Baranov, Victor and Morukov, Boris and Eckhardt, Kai-Uwe and Vassilieva, Galina and Wabel, Peter and Vienken, J. and Kirsch, K. and Johannes, Bernd and Krannich, Alexander and Luft, Friedrich C. (2015) Agreement Between 24-Hour Salt Ingestion and Sodium Excretion in a Controlled Environment. Hypertension, 66 (4), pp. 850-857. American Heart Association, Inc.. DOI: 10.1161/HYPERTENSIONAHA.115.05851 ISSN 0194-911X

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Abstract

Accurately collected 24-hour urine collections are presumed to be valid for estimating salt intake in individuals. We performed 2 independent ultralong-term salt balance studies lasting 105 (4 men) and 205 (6 men) days in 10 men simulating a flight to Mars. We controlled dietary intake of all constituents for months at salt intakes of 12, 9, and 6 g/d and collected all urine. The subjects' daily menus consisted of 27 279 individual servings, of which 83.0% were completely consumed, 16.5% completely rejected, and 0.5% incompletely consumed. Urinary recovery of dietary salt was 92% of recorded intake, indicating long-term steady-state sodium balance in both studies. Even at fixed salt intake, 24-hour urine collection for sodium excretion (UNaV) showed infradian rhythmicity. We defined a ±25 mmol deviation from the average difference between recorded sodium intake and UNaV as the prediction interval to accurately classify a 3-g difference in salt intake. Because of the biological variability in UNaV, only every other daily urine sample correctly classified a 3-g difference in salt intake (49%). By increasing the observations to 3 consecutive 24-hour collections and sodium intakes, classification accuracy improved to 75%. Collecting seven 24-hour urines and sodium intake samples improved classification accuracy to 92%. We conclude that single 24-hour urine collections at intakes ranging from 6 to 12 g salt per day were not suitable to detect a 3-g difference in individual salt intake. Repeated measurements of 24-hour UNaV improve precision. This knowledge could be relevant to patient care and the conduct of intervention trials.

Item URL in elib:https://elib.dlr.de/98127/
Document Type:Article
Title:Agreement Between 24-Hour Salt Ingestion and Sodium Excretion in a Controlled Environment
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Lerchl, KathrinUNSPECIFIEDUNSPECIFIED
Rakova, NataliaUNSPECIFIEDUNSPECIFIED
Dahlmann, AnkeUNSPECIFIEDUNSPECIFIED
Rauh, ManfredUniversität ErlangenUNSPECIFIED
Goller, U.UNSPECIFIEDUNSPECIFIED
Basner, MathiasUNSPECIFIEDUNSPECIFIED
Dinges, David F.UNSPECIFIEDUNSPECIFIED
Beck, LuisGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Agureev, A.UNSPECIFIEDUNSPECIFIED
Larina, IrinaIBMP, Moscow, RussiaUNSPECIFIED
Baranov, VictorUNSPECIFIEDUNSPECIFIED
Morukov, BorisIBMPUNSPECIFIED
Eckhardt, Kai-UweUNSPECIFIEDUNSPECIFIED
Vassilieva, GalinaIBMPUNSPECIFIED
Wabel, PeterUNSPECIFIEDUNSPECIFIED
Vienken, J.UNSPECIFIEDUNSPECIFIED
Kirsch, K.Badlands Observatory, USAUNSPECIFIED
Johannes, BerndDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, bernd.johannes (at) dlr.deUNSPECIFIED
Krannich, AlexanderUNSPECIFIEDUNSPECIFIED
Luft, Friedrich C.Franz-Volhard Clinical Research Center, Medical University Charité, Campus Buch, Berlin, GermanyUNSPECIFIED
Date:2015
Journal or Publication Title:Hypertension
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:66
DOI :10.1161/HYPERTENSIONAHA.115.05851
Page Range:pp. 850-857
Publisher:American Heart Association, Inc.
ISSN:0194-911X
Status:Published
Keywords:dietary; hypertension; salt; sodium; urine specimen collection
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:07 Jan 2016 16:37
Last Modified:06 Sep 2019 15:19

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