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Muscular forces affect the glycosaminoglycan content of joint cartilage

Ganse, Bergita and Zange, Jochen and Weber, Tobias and Pohle-Fröhlich, Regina and Johannes, Bernd and Hackenbroch, Matthias and Rittweger, Jörn and Eysel, Peer and Koy, Timmo (2015) Muscular forces affect the glycosaminoglycan content of joint cartilage. Acta Orthopaedica, 86 (3), pp. 388-392. Nordic Orthopaedic Federation. ISSN 1745-3674

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Abstract

BACKGROUND AND PURPOSE: Unloading alters the thickness of joint cartilage. It is unknown, however, to what extent unloading leads to a loss of glycosaminoglycans (GAGs) in the cartilage tissue. We hypothesized that muscle forces, in addition to axial loading, are necessary to maintain the joint cartilage GAG content of the knee and the upper and lower ankle. PATIENTS AND METHODS: The HEPHAISTOS orthosis was worn unilaterally by 11 men (mean age 31 (23-50) years old) for 56 days. The orthosis reduces activation and force production of the calf muscles while it permits full gravitational loading of the lower leg. MRI measurements of the knee and ankle were taken before the intervention, during the intervention (on day 49), and 14 days after the end of the intervention. Cartilage segmentation was conducted semiautomatically for the knee joint (4 segments) and for the upper (tibio-talar) and lower (subtalar) ankle joints (2 segments each). Linear mixed-effects (LME) models were used for statistical analysis. RESULTS: 8 volunteers completed the MRI experiment. In the lower ankle joint, differences in ΔT1 were found between the end of the intervention and 14 days after (p = 0.004), indicating a decrease in GAG content after reloading. There were no statistically significant differences in ΔT1 values in the knee and upper ankle joints. INTERPRETATION: Our findings suggest that in addition to gravitational load, muscular forces affect cartilage composition depending on the local distribution of forces in the joints affected by muscle contraction

Item URL in elib:https://elib.dlr.de/97209/
Document Type:Article
Title:Muscular forces affect the glycosaminoglycan content of joint cartilage
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Ganse, BergitaDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, Cologne, bergita.ganse (at) dlr.deUNSPECIFIED
Zange, JochenDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR ), Cologne; jochen.zange (at) dlr.deUNSPECIFIED
Weber, TobiasDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR ), Cologne and European Astronaut CenterUNSPECIFIED
Pohle-Fröhlich, ReginaHochschule Niederrhein, Institute for Pattern Recognition, KrefeldUNSPECIFIED
Johannes, BerndDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, bernd.johannes (at) dlr.deUNSPECIFIED
Hackenbroch, MatthiasUniversity of Cologne, Department of Radiology, CologneUNSPECIFIED
Rittweger, JörnDivision Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR ), Cologne and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Eysel, PeerUniversity of Cologne, Department of Orthopaedic and Trauma Surgery, CologneUNSPECIFIED
Koy, TimmoDepartment of Orthopedic and Trauma Surgery, University of Cologne, Cologne, Germany, timmo.koy (at) uk-koeln.deUNSPECIFIED
Date:2015
Journal or Publication Title:Acta Orthopaedica
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:86
Page Range:pp. 388-392
Editors:
EditorsEmail
Lund, Rydholm AndersUNSPECIFIED
Odense, Peter A FrandsenUNSPECIFIED
Publisher:Nordic Orthopaedic Federation
ISSN:1745-3674
Status:Published
Keywords:Muscular forces, glycosaminoglycan, orthosis
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:14 Jul 2015 11:31
Last Modified:14 Jul 2015 11:31

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