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Short-arm centrifugation as a partially effective musculoskeletal countermeasure during 5-day head-down tilt bed rest - results from the BRAG1 study

Rittweger, J. and Bareille, M.P. and Clément, G. and Linnarsson, D. and Paloski, W. and Wuyts, F.L. and Zange, J. and Angerer, O. (2015) Short-arm centrifugation as a partially effective musculoskeletal countermeasure during 5-day head-down tilt bed rest - results from the BRAG1 study. European Journal of Applied Physiology, 115 (6), pp. 1233-1244. Springer. ISSN 1439-6319

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Abstract

PURPOSE: Human centrifugation, also called artificial gravity (AG), is proposed as a combined strategy against detrimental effects of microgravity in long-term space missions. This study scrutinized human short-arm centrifugation as countermeasure against musculoskeletal de-conditioning. METHOD: Eleven healthy male subjects [mean age of 34 (SD 7) years] completed the cross-over trial, including three campaigns of -6° head-down tilt bed rest (HDT) for 5 days, with preceding baseline data collection and recovery phases. Bed rest without AG was used as control condition (Ctrl), and AG with 1 g at the center of mass applied once per day for 30 min in one bout (AG1×30) and in 6 bouts of 5 min (AG6×5, 3-min rest between bouts) as experimental conditions. End-points were muscle strength, vertical jump performance, and biomarkers of bone and protein metabolism. RESULT: AG6×5 was better tolerated than AG1×30. Bone resorption markers CTX, NTX, and DPD all increased by approximately 25 % toward the end of bed rest (P < 0.001), and nitrogen balance decreased by approximately 3 g/day (P < 0.001), without any protection by AG (P > 0.4). Decreases in vertical jump height by 2.1 (SE 0.6) cm after Ctrl bed rest was prevented by either of the AG protocols (P = 0.039). CONCLUSION: The present study yielded succinct catabolic effects upon muscle and bone metabolism that were un-prevented by AG. The preservation of vertical jump performance by AG in this study is likely caused by central nervous rather than by peripheral musculoskeletal effects.

Item URL in elib:https://elib.dlr.de/97208/
Document Type:Article
Title:Short-arm centrifugation as a partially effective musculoskeletal countermeasure during 5-day head-down tilt bed rest - results from the BRAG1 study
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Rittweger, J.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Bareille, M.P.French Institute for Space Medicine and Physiology (MEDES) Clinique Spatiale, Toulouse, FranceUNSPECIFIED
Clément, G.International Space University, Strasbourg, France, EUUNSPECIFIED
Linnarsson, D.Karolinska Institutet, Dept. of Physiology and Pharmacology, Sect. of Environmental PhysiologyUNSPECIFIED
Paloski, W.University of HoustonUNSPECIFIED
Wuyts, F.L.UNSPECIFIEDUNSPECIFIED
Zange, J.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, Germany and Medical Faculty of the University of Cologne, Cologne, Germany; jochen.zange (at) dlr.deUNSPECIFIED
Angerer, O.ESA, ESTEC, HSF-USL Nordwijk The NetherlandsUNSPECIFIED
Date:2015
Journal or Publication Title:European Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:115
Page Range:pp. 1233-1244
Editors:
EditorsEmail
Westerblad, HUNSPECIFIED
Westerterp, K. R.UNSPECIFIED
Publisher:Springer
ISSN:1439-6319
Status:Published
Keywords:Posturography, Balance, Bed Rest, Centrifugation, Artificial Gravity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:14 Jul 2015 11:10
Last Modified:06 Sep 2019 15:25

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