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Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training

Mulder, E. and Clément, G. and Linnarsson, D. and Paloski, W. and Wuyts, F.L. and Zange, J. and Frings-Meuthen, P. and Johannes, B. and Shushakov, V. and Grunewald, M. and Maassen, N. and Buehlmeier, J. and Rittweger, J. (2015) Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training. European Journal of Applied Physiology, 115 (4), pp. 727-738. Springer. DOI: 10.1007/s00421-014-3045-0 ISSN 1439-6319

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Abstract

OBJECTIVES: The present study evaluated the effectiveness of a short and versatile daily exercise regime, named locomotion replacement training (LRT), to maintain muscle size, isometric strength, power, and endurance capacity of the leg muscles following 5 days of head-down tilt (HDT) bed rest. METHODS: 10 male subjects (age 29.4 ± 5.9 years; height 178.8 ± 3.7 cm; body mass 77.7 ± 4.1 kg) performed, in random order, 5 days of 6° head-down tilt bed rest (BR) with no exercise (CON), or BR with daily 25 min of upright standing (STA) or LRT. RESULTS: Knee extensor and plantar flexor cross-sectional area (CSA) were reduced by 2-3 % following bed rest (P < 0.01) for CON and STA, yet maintained for LRT. Knee extensor isometric strength (MVC) decreased by 8 % for CON (P < 0.05), was maintained for STA, and increased with 12 % for LRT (P < 0.05). Plantar flexor MVC remained unaltered during the study. Maximum jump height declined (~1.5 cm) for all conditions (P < 0.001). Neural activation and knee extensor fatigability did not change with bed rest. Bone resorption increased during BR and neither LRT nor STA was able to prevent or attenuate this increase. CONCLUSION: LRT was adequate to maintain muscle size and to even increase knee extensor MVC, but not muscle power and bone integrity, which likely requires more intense and/or longer exercise regimes. However, with only some variables showing significant changes, we conclude that 5 days of BR is an inadequate approach for countermeasure assessments.

Item URL in elib:https://elib.dlr.de/97205/
Document Type:Article
Title:Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Mulder, E.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Clément, G.International Space University, Strasbourg, France, EUUNSPECIFIED
Linnarsson, D.Karolinska Institutet, Dept. of Physiology and Pharmacology, Sect. of Environmental PhysiologyUNSPECIFIED
Paloski, W.University of HoustonUNSPECIFIED
Wuyts, F.L.UNSPECIFIEDUNSPECIFIED
Zange, J.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, Germany and Medical Faculty of the University of Cologne, Cologne, Germany; jochen.zange (at) dlr.deUNSPECIFIED
Frings-Meuthen, P.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Johannes, B.bernd.johannes (at) dlr.deUNSPECIFIED
Shushakov, V.Medizinische Hochschule HannoverUNSPECIFIED
Grunewald, M.UNSPECIFIEDUNSPECIFIED
Maassen, N.Dep. Sports Physiology, Medical School, Hannover, GermanyUNSPECIFIED
Buehlmeier, J.German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Rittweger, J.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Date:2015
Journal or Publication Title:European Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:115
DOI :10.1007/s00421-014-3045-0
Page Range:pp. 727-738
Editors:
EditorsEmail
Westerblad, HUNSPECIFIED
Westerterp, K. R.UNSPECIFIED
Publisher:Springer
ISSN:1439-6319
Status:Published
Keywords:Hypokinesia, Exercise countermeasure, Skeletal muscle, Bone markers, Fatigability
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:14 Jul 2015 10:53
Last Modified:06 Sep 2019 15:25

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