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Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults

Reina, P. and Cointry, G.R. and Nocciolono, L.M. and Feldman, S. and Ferretti, J.L. and Rittweger, J. and Capozza, R.F. (2015) Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults. Journal of Musculoskeletal and Neuronal Interactions, 15 (1), pp. 10-22. International Society of Musculoskeletal and Neuronal Interactions. ISSN 1108-7161

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Abstract

To compare the independent influence of mechanical and non-mechanical factors on bone features, multiple regression analyses were performed between pQCT indicators of radius and tibia bone mass, mineralization, design and strength as determined variables, and age or time since menopause (TMP), body mass, bone length and regional muscles’ areas as selected determinant factors, in Caucasian, physically active, untrained healthy men and pre- and post-menopausal women. In men and pre-menopausal women, the strongest influences were exerted by muscle area on radial features and by both muscle area and bone length on the tibia. Only for women, was body mass a significant factor for tibia traits. In men and pre-menopausal women, mass/design/strength indicators depended more strongly on the selected determinants than the cortical vBMD did (p<0.01-0.001 vs n.s.), regardless of age. However, TMP was an additional factor for both bones (p<0.01-0.001). The selected mechanical factors (muscle size, bone lengths) were more relevant than age/TMP or body weight to the development of allometrically-related bone properties (mass/design/strength), yet not to bone tissue “quality” (cortical vBMD), suggesting a determinant, rather than determined role for cortical stiffness. While the mechanical impacts of muscles and bone levers on bone structure were comparable in men and pre-menopausal women, TMP exerted a stronger impact than allometric or mechanical factors on bone properties, including cortical vBMD.

Item URL in elib:https://elib.dlr.de/97202/
Document Type:Article
Title:Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Reina, P.National University of Rosario (UNR)UNSPECIFIED
Cointry, G.R.National University of RosarioUNSPECIFIED
Nocciolono, L.M.CEMFoCUNSPECIFIED
Feldman, S.University of RosarioUNSPECIFIED
Ferretti, J.L.Center of P-Ca Metabolism Studies (CEMFoC), jlferretti (at) arnet.com.arUNSPECIFIED
Rittweger, J.Institute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Capozza, R.F.University of RosarioUNSPECIFIED
Date:16 February 2015
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:15
Page Range:pp. 10-22
Editors:
EditorsEmail
Webster, S. S. JeeUNSPECIFIED
Publisher:International Society of Musculoskeletal and Neuronal Interactions
ISSN:1108-7161
Status:Published
Keywords:Muscle-Bone Interactions, Bone Biomechanics, Bone Tomography, QCT, pQCT, Osteoporosis
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:14 Jul 2015 10:37
Last Modified:10 Jan 2019 15:51

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