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227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?

Cleaves, H. James und Meringer, Markus und Goodwin, Jay T. (2015) 227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space? AbSciCon - Astrobiology Science Conference 2015, 2015-07-15 - 2015-07-19, Chicago, IL, USA.

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Offizielle URL: http://www.hou.usra.edu/meetings/abscicon2015/pdf/7761.pdf

Kurzfassung

Ribonucleic Acid (RNA) is one of the two nucleic acids used by extant biochemistry, and plays a central role as the intermediary carrier of genet-ic information in transcription and translation. If RNA was involved in the origin of life, it should have a facile prebiotic synthesis. A wide variety of such syntheses have been explored. However, to date no one-pot reaction has been shown capable of yielding RNA monomers from likely prebiotically-abundant starting materials, though this does not rule out the possibility that simpler, more easily prebiotically-accessible nucleic acids may have preceded RNA. Given structural constraints, such as the ability to form complementary base-pairs and a linear covalent polymer, a variety of structural isomers of RNA could potentially function as genetic platforms. Using structure generation software, all of the potential structural isomers of the ribosides (BC5H9O4, where B is nucleobase), as well as a set of simpler minimal analogues derived from them, that can potentially serve as mono-meric building blocks of nucleic acid-like molecules were enumerated. Molecules were selected based on their likely stability under biochemically relevant conditions (e.g. moderate pH and temperature), and the presence of at least two functional groups allowing the monomers to be incorporated into linear polymers. The resulting structures were then evaluated using molecular descriptors typically applied in quantitative structure–property relationship (QSPR) studies and predicted physicochemical properties. Several databases were queried to see if any of the computed isomers had been synthesized previously. Very few of the molecules that emerged from this structure set have been previously described. We conclude that ribonucleosides may have competed with a multitude of alternative structures whose potential proto-biochemical roles and abiotic syntheses remain to be explored.

elib-URL des Eintrags:https://elib.dlr.de/96673/
Dokumentart:Konferenzbeitrag (Vortrag)
Titel:227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Cleaves, H. JamesEarth-Life Science Institute, Tokyo Institute of TechnologyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Meringer, MarkusMarkus.Meringer (at) dlr.dehttps://orcid.org/0000-0001-8526-2429NICHT SPEZIFIZIERT
Goodwin, Jay T.Emory UniversityNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:2015
Referierte Publikation:Nein
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:ribonucleic acid, origin of life, structure generation software, molecular descriptors, databases
Veranstaltungstitel:AbSciCon - Astrobiology Science Conference 2015
Veranstaltungsort:Chicago, IL, USA
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:15 Juli 2015
Veranstaltungsende:19 Juli 2015
Veranstalter :USRA
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:keine Zuordnung
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R - keine Zuordnung
DLR - Teilgebiet (Projekt, Vorhaben):R - keine Zuordnung, R - Atmosphären- und Klimaforschung
Standort: Oberpfaffenhofen
Institute & Einrichtungen:Institut für Methodik der Fernerkundung > Atmosphärenprozessoren
Hinterlegt von: Meringer, Dr.rer.nat. Markus
Hinterlegt am:18 Jun 2015 12:53
Letzte Änderung:24 Apr 2024 20:02

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