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Stress-induced DNA damage biomarkers: applications and limitations

Nikitaki, Zacharenia and Hellweg, Christine E. and Georgakilas, Alexandros G. and Ravanat, Jean-Luc (2015) Stress-induced DNA damage biomarkers: applications and limitations. Frontiers in Chemistry, 3:35. Frontiers Media S.A.. DOI: 10.3389/fchem.2015.00035 ISSN 2296-2646

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Official URL: http://dx.doi.org/10.3389/fchem.2015.00035

Abstract

A variety of environmental stresses like chemicals, UV and ionizing radiation and organism's endogenous processes such as replication stress and metabolism can lead to the generation of reactive oxygen and nitrogen species (ROS/RNS) that can attack cellular vital components like DNA, proteins and lipid membranes. Among them, much attention has been focused on DNA since DNA damage plays a role in several biological disorders and aging processes. Thus, DNA damage can be used as a biomarker in a reliable and accurate way to quantify for example radiation exposure and can indicate its possible long term effects and cancer risk. Based on the type of DNA lesions detected one can hypothesize on the most probable mechanisms involved in the formation of these lesions for example in the case of UV and ionizing radiation (e.g., X- or α-, γ-rays, energetic ions, neutrons). In this review we describe the most accepted chemical pathways for DNA damage induction and the different types of DNA lesions, i.e., single, complex DNA lesions etc. that can be used as DNA damage biomarkers. We critically compare DNA damage detection methods and their limitations. In addition, we suggest the use of DNA repair gene products as biomarkes for identification of different types of stresses i.e., radiation, oxidative, or replication stress, based on bioinformatic approaches and meta-analysis of literature data.

Item URL in elib:https://elib.dlr.de/96521/
Document Type:Article
Title:Stress-induced DNA damage biomarkers: applications and limitations
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Nikitaki, ZachareniaDNA Damage and Repair Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Athens, GreeceUNSPECIFIED
Hellweg, Christine E.Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, Köln, GermanyUNSPECIFIED
Georgakilas, Alexandros G.DNA Damage and Repair Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Athens, GreeceUNSPECIFIED
Ravanat, Jean-LucLaboratoire des Lésions des Acides Nucléiques, Institut des Nanosciences et Cryogénie, Service de Chimie Inorgranique et Biologique, Université Grenoble Alpes, Grenoble, France and CEA, Institut des Nanosciences et Cryogénie, Grenoble, FranceUNSPECIFIED
Date:2015
Journal or Publication Title:Frontiers in Chemistry
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:3:35
DOI :10.3389/fchem.2015.00035
Publisher:Frontiers Media S.A.
ISSN:2296-2646
Status:Published
Keywords:DNA damage, oxidative stress, biomarkers, ionizing radiation, UV radiation, clustered DNA lesions
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:16 Jul 2015 15:06
Last Modified:20 Dec 2016 05:01

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