elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Impressum | Datenschutz | Kontakt | English Sonntag, 29. Dezember 2024
Schriftgröße: [-] Text [+]

Stress-induced DNA damage biomarkers: applications and limitations

Nikitaki, Zacharenia und Hellweg, Christine E. und Georgakilas, Alexandros G. und Ravanat, Jean-Luc (2015) Stress-induced DNA damage biomarkers: applications and limitations. Frontiers in Chemistry, 3:35. Frontiers Media S.A.. doi: 10.3389/fchem.2015.00035. ISSN 2296-2646.

Dieses Archiv kann nicht den Volltext zur Verfügung stellen.

Offizielle URL: http://dx.doi.org/10.3389/fchem.2015.00035

Kurzfassung

A variety of environmental stresses like chemicals, UV and ionizing radiation and organism's endogenous processes such as replication stress and metabolism can lead to the generation of reactive oxygen and nitrogen species (ROS/RNS) that can attack cellular vital components like DNA, proteins and lipid membranes. Among them, much attention has been focused on DNA since DNA damage plays a role in several biological disorders and aging processes. Thus, DNA damage can be used as a biomarker in a reliable and accurate way to quantify for example radiation exposure and can indicate its possible long term effects and cancer risk. Based on the type of DNA lesions detected one can hypothesize on the most probable mechanisms involved in the formation of these lesions for example in the case of UV and ionizing radiation (e.g., X- or α-, γ-rays, energetic ions, neutrons). In this review we describe the most accepted chemical pathways for DNA damage induction and the different types of DNA lesions, i.e., single, complex DNA lesions etc. that can be used as DNA damage biomarkers. We critically compare DNA damage detection methods and their limitations. In addition, we suggest the use of DNA repair gene products as biomarkes for identification of different types of stresses i.e., radiation, oxidative, or replication stress, based on bioinformatic approaches and meta-analysis of literature data.

elib-URL des Eintrags:https://elib.dlr.de/96521/
Dokumentart:Zeitschriftenbeitrag
Titel:Stress-induced DNA damage biomarkers: applications and limitations
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iD
Nikitaki, ZachareniaDNA Damage and Repair Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Athens, Greece
Hellweg, Christine E.Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, Köln, Germany
Georgakilas, Alexandros G.DNA Damage and Repair Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Athens, Greece
Ravanat, Jean-LucLaboratoire des Lésions des Acides Nucléiques, Institut des Nanosciences et Cryogénie, Service de Chimie Inorgranique et Biologique, Université Grenoble Alpes, Grenoble, France and CEA, Institut des Nanosciences et Cryogénie, Grenoble, France
Datum:2015
Erschienen in:Frontiers in Chemistry
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Ja
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:3:35
DOI:10.3389/fchem.2015.00035
Verlag:Frontiers Media S.A.
ISSN:2296-2646
Status:veröffentlicht
Stichwörter:DNA damage, oxidative stress, biomarkers, ionizing radiation, UV radiation, clustered DNA lesions
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Strahlenbiologie (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:16 Jul 2015 15:06
Letzte Änderung:20 Dez 2016 05:01

Nur für Mitarbeiter des Archivs: Kontrollseite des Eintrags

Einige Felder oben sind zurzeit ausgeblendet: Alle Felder anzeigen
Blättern
Suchen
Hilfe & Kontakt
Informationen
electronic library verwendet EPrints 3.3.12
Gestaltung Webseite und Datenbank: Copyright © Deutsches Zentrum für Luft- und Raumfahrt (DLR). Alle Rechte vorbehalten.