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The Nuclear Factor κB pathway: A link to the immune system in the radiation response

Hellweg, Christine E. (2015) The Nuclear Factor κB pathway: A link to the immune system in the radiation response. Cancer Letters, 368, pp. 275-289. Elsevier. doi: 10.1016/j.canlet.2015.02.019. ISSN 0304-3835.

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1016/j.canlet.2015.02.019


Exposure to ionizing radiation modulates immune responses in a complex dose-dependent pattern, with possible anti-inflammatory effects in the low dose range, expression of pro-inflammatory cytokines at moderate doses and immunosuppression after exposure to higher doses due to precursor cell death together with concomitant exacerbated innate immune responses. A central regulator in the immune system is the transcription factor Nuclear Factor κB (NF-κB). NF-κB is involved in the regulation of cellular survival, immune responses and inflammation, resulting in eminent importance in cancerogenesis. After exposure to ionizing radiation, NF-κB activation is initially triggered by ATM which is activated by DNA double strand breaks. Together with the NF-κB essential modulator (NEMO), it serves as a nucleoplasmic shuttle. The pathway converges with the classical NF-κB pathway at IκB kinase (IKK) complex activation. Resulting cytokine expression can activate NF-κB in a positive feed forward loop. Danger signals released from dying cells can activate NF-κB via Toll-like receptors (TLRs). The resulting immune activation can be beneficial or detrimental. In the low dose range, pro- and anticancerogenic effects are possible. In the radiotherapy-relevant dose range, tolerogenic immune responses should be avoided, and an antitumor immune response might be supported by TLR agonists activating NF-κB.

Item URL in elib:https://elib.dlr.de/95586/
Document Type:Article
Additional Information:Epub ahead of print (in Press)
Title:The Nuclear Factor κB pathway: A link to the immune system in the radiation response
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Hellweg, Christine E.German Aerospace Centre (DLR), Institute of Aerospace Medicine, Radiation Biology, Linder Höhe, Köln D-51147, Germany; christine.hellweg (at) dlr.deUNSPECIFIED
Journal or Publication Title:Cancer Letters
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
DOI :10.1016/j.canlet.2015.02.019
Page Range:pp. 275-289
Keywords:Nuclear Factor κB, Immune system, Cellular radiation response, Linear energy transfer, Bystander effect, Chemokines
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:16 Mar 2015 12:47
Last Modified:07 Oct 2015 10:15

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