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The Nuclear Factor κB pathway: A link to the immune system in the radiation response

Hellweg, Christine E. (2015) The Nuclear Factor κB pathway: A link to the immune system in the radiation response. Cancer Letters, 368, pp. 275-289. Elsevier. doi: 10.1016/j.canlet.2015.02.019. ISSN 0304-3835.

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1016/j.canlet.2015.02.019


Exposure to ionizing radiation modulates immune responses in a complex dose-dependent pattern, with possible anti-inflammatory effects in the low dose range, expression of pro-inflammatory cytokines at moderate doses and immunosuppression after exposure to higher doses due to precursor cell death together with concomitant exacerbated innate immune responses. A central regulator in the immune system is the transcription factor Nuclear Factor κB (NF-κB). NF-κB is involved in the regulation of cellular survival, immune responses and inflammation, resulting in eminent importance in cancerogenesis. After exposure to ionizing radiation, NF-κB activation is initially triggered by ATM which is activated by DNA double strand breaks. Together with the NF-κB essential modulator (NEMO), it serves as a nucleoplasmic shuttle. The pathway converges with the classical NF-κB pathway at IκB kinase (IKK) complex activation. Resulting cytokine expression can activate NF-κB in a positive feed forward loop. Danger signals released from dying cells can activate NF-κB via Toll-like receptors (TLRs). The resulting immune activation can be beneficial or detrimental. In the low dose range, pro- and anticancerogenic effects are possible. In the radiotherapy-relevant dose range, tolerogenic immune responses should be avoided, and an antitumor immune response might be supported by TLR agonists activating NF-κB.

Item URL in elib:https://elib.dlr.de/95586/
Document Type:Article
Additional Information:Epub ahead of print (in Press)
Title:The Nuclear Factor κB pathway: A link to the immune system in the radiation response
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Journal or Publication Title:Cancer Letters
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:pp. 275-289
Keywords:Nuclear Factor κB, Immune system, Cellular radiation response, Linear energy transfer, Bystander effect, Chemokines
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:16 Mar 2015 12:47
Last Modified:07 Oct 2015 10:15

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