Hellweg, Christine E. (2015) The Nuclear Factor κB pathway: A link to the immune system in the radiation response. Cancer Letters, 368, Seiten 275-289. Elsevier. doi: 10.1016/j.canlet.2015.02.019. ISSN 0304-3835.
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Offizielle URL: http://dx.doi.org/10.1016/j.canlet.2015.02.019
Kurzfassung
Exposure to ionizing radiation modulates immune responses in a complex dose-dependent pattern, with possible anti-inflammatory effects in the low dose range, expression of pro-inflammatory cytokines at moderate doses and immunosuppression after exposure to higher doses due to precursor cell death together with concomitant exacerbated innate immune responses. A central regulator in the immune system is the transcription factor Nuclear Factor κB (NF-κB). NF-κB is involved in the regulation of cellular survival, immune responses and inflammation, resulting in eminent importance in cancerogenesis. After exposure to ionizing radiation, NF-κB activation is initially triggered by ATM which is activated by DNA double strand breaks. Together with the NF-κB essential modulator (NEMO), it serves as a nucleoplasmic shuttle. The pathway converges with the classical NF-κB pathway at IκB kinase (IKK) complex activation. Resulting cytokine expression can activate NF-κB in a positive feed forward loop. Danger signals released from dying cells can activate NF-κB via Toll-like receptors (TLRs). The resulting immune activation can be beneficial or detrimental. In the low dose range, pro- and anticancerogenic effects are possible. In the radiotherapy-relevant dose range, tolerogenic immune responses should be avoided, and an antitumor immune response might be supported by TLR agonists activating NF-κB.
elib-URL des Eintrags: | https://elib.dlr.de/95586/ | ||||||||
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Dokumentart: | Zeitschriftenbeitrag | ||||||||
Zusätzliche Informationen: | Epub ahead of print (in Press) | ||||||||
Titel: | The Nuclear Factor κB pathway: A link to the immune system in the radiation response | ||||||||
Autoren: |
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Datum: | 2015 | ||||||||
Erschienen in: | Cancer Letters | ||||||||
Referierte Publikation: | Ja | ||||||||
Open Access: | Nein | ||||||||
Gold Open Access: | Nein | ||||||||
In SCOPUS: | Ja | ||||||||
In ISI Web of Science: | Ja | ||||||||
Band: | 368 | ||||||||
DOI: | 10.1016/j.canlet.2015.02.019 | ||||||||
Seitenbereich: | Seiten 275-289 | ||||||||
Verlag: | Elsevier | ||||||||
ISSN: | 0304-3835 | ||||||||
Status: | veröffentlicht | ||||||||
Stichwörter: | Nuclear Factor κB, Immune system, Cellular radiation response, Linear energy transfer, Bystander effect, Chemokines | ||||||||
HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||
HGF - Programm: | Raumfahrt | ||||||||
HGF - Programmthema: | Forschung unter Weltraumbedingungen | ||||||||
DLR - Schwerpunkt: | Raumfahrt | ||||||||
DLR - Forschungsgebiet: | R FR - Forschung unter Weltraumbedingungen | ||||||||
DLR - Teilgebiet (Projekt, Vorhaben): | R - Vorhaben Strahlenbiologie (alt) | ||||||||
Standort: | Köln-Porz | ||||||||
Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie | ||||||||
Hinterlegt von: | Kopp, Kerstin | ||||||||
Hinterlegt am: | 16 Mär 2015 12:47 | ||||||||
Letzte Änderung: | 06 Nov 2023 09:53 |
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