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Prediction of bone strength by μCT and MDCT-based finite-element-models: How much spatial resolution is needed?

Bauer, Jan S. and Sidorenko, Irina and Mueller, Dirk and Baum, Thomas and Issever, Ahi Sema and Eckstein, Felix and Rummeny, Ernst J. and Link, Thomas M. and Räth, Christoph (2014) Prediction of bone strength by μCT and MDCT-based finite-element-models: How much spatial resolution is needed? European Journal of Radiology, 83 (1), e36-e42. Elsevier. ISSN 0720-048X

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Official URL: http://dx.doi.org/10.1016/j.ejrad.2013.10.024

Abstract

OBJECTIVES: Finite-element-models (FEM) are a promising technology to predict bone strength and fracture risk. Usually, the highest spatial resolution technically available is used, but this requires excessive computation time and memory in numerical simulations of large volumes. Thus, FEM were compared at decreasing resolutions with respect to local strain distribution and prediction of failure load to (1) validate MDCT-based FEM and to (2) optimize spatial resolution to save computation time. MATERIALS AND METHODS: 20 cylindrical trabecular bone specimens (diameter 12 mm, length 15-20mm) were harvested from elderly formalin-fixed human thoracic spines. All specimens were examined by micro-CT (isotropic resolution 30 μm) and whole-body multi-row-detector computed tomography (MDCT, 250 μm × 250 μm × 500 μm). The resolution of all datasets was lowered in eight steps to ~ 2,000 μm × 2000 μm × 500 μm and FEM were calculated at all resolutions. Failure load was determined by biomechanical testing. Probability density functions of local micro-strains were compared in all datasets and correlations between FEM-based and biomechanically measured failure loads were determined. RESULTS: The distribution of local micro-strains was similar for micro-CT and MDCT at comparable resolutions and showed a shift toward higher average values with decreasing resolution, corresponding to the increasing apparent trabecular thickness. Small micro-strains (εeff<0.005) could be calculated down to 250 μm × 250 μm × 500 μm. Biomechanically determined failure load showed significant correlations with all FEM, up to r=0.85 and did not significantly change with lower resolution but decreased with high thresholds, due to loss of trabecular connectivity. CONCLUSION: When choosing connectivity-preserving thresholds, both micro-CT- and MDCT-based finite-element-models well predicted failure load and still accurately revealed the distribution of local micro-strains in spatial resolutions, available in vivo (250 μm × 250 μm × 500 μm), that thus seemed to be the optimal compromise between high accuracy and low computation time.

Item URL in elib:https://elib.dlr.de/95410/
Document Type:Article
Title:Prediction of bone strength by μCT and MDCT-based finite-element-models: How much spatial resolution is needed?
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Bauer, Jan S.Technische Universität München, GermanyUNSPECIFIED
Sidorenko, IrinaMax Planck Institut für extraterrestriesche Physik, Garching, GermanyUNSPECIFIED
Mueller, DirkUniversität Köln, GermanyUNSPECIFIED
Baum, ThomasTechnische Universität München, GermanyUNSPECIFIED
Issever, Ahi SemaUniversity of California, San Francisco, USAUNSPECIFIED
Eckstein, FelixParacelsus Medical University, Salzburg, AustriaUNSPECIFIED
Rummeny, Ernst J.Technische Universität München, GermanyUNSPECIFIED
Link, Thomas M.University of California, San Francisco, USAUNSPECIFIED
Räth, ChristophDLR Research Group Complex Plasma, OberpfaffenhofenUNSPECIFIED
Date:2014
Journal or Publication Title:European Journal of Radiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:83
Page Range:e36-e42
Publisher:Elsevier
ISSN:0720-048X
Status:Published
Keywords:Bone structure, FEM, data analysis
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Komplexe Plasmen / Data analysis
Location: Oberpfaffenhofen
Institutes and Institutions:Research Group Complex Plasma
Deposited By: Räth, Christoph
Deposited On:03 Mar 2015 09:32
Last Modified:08 Mar 2018 18:37

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