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Associations between Quantitative Sleep EEG Data and Subsequent Cognitive Decline in Community-Dwelling Older Women

Djonlagic, I. and Aeschbach, D. and Litwack Harrison, S. and Dean, D. and Yaffe, K. and Ancoli-Israel, Sonia and Stone, Katie and Redline, S. (2014) Associations between Quantitative Sleep EEG Data and Subsequent Cognitive Decline in Community-Dwelling Older Women. In: Journal of Sleep and Sleep Disorders Research, A339. 28th Annual Meeting of the Associated Professional Sleep Societies, LLC, 31.05.-01.06.14, Minneapolis, USA. ISSN 0161-8105

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Abstract

Introduction: Healthy aging is associated with changes in both circadian and homeostatic sleep regulatory processes as well as a higher prevalence of sleep disorders, which in turn can accelerate the aging process and increase the risk for cognitive impairment. EEG power spectrum can provide additional information regarding the memory consolidation processes compared to the traditional sleep scoring. This study examined whether quantitative sleep EEG traits predict development of mild cognitive impairment (MCI) and/or incident dementia. Methods: Participants consisted of a randomly selected subgroup of women (mean age 83 yrs) from the Sleep and Cognition Study, an ancillary study to the longitudinal Study of Osteoporotic Fractures (SOF), who were free of cognitive impairment at the time of a baseline polysomnography study (SOF Visit 8). Cases (n=85) were women who developed mild MCI or dementia by objective testing at an exam 4 years after polysomnography. Controls were those with no MCI/Dementia (n=85). Absolute power for EEG frequency bands were generated using off-line spectral analysis based on a Fast-Fourier Transform (FFT) Routine (Vitascore, TEMEC). Results: At Visit 8, groups did not differ in age, BMI, education, co-morbidities, subjective sleepiness, sleep architecture as well as respiratory disturbance, arousal and periodic limb movement indices. Differences in EEG power density during nonREM sleep were observed over a broad frequency range, with higher values in the Dementia/MCI group particularly in the alpha band (8-12Hz;p=0.003), but also in the sigma (12-15Hz;p=0.04) and theta (4-8Hz;p=0.03) bands, and for slow wave activity (0.75-4.5Hz) during the first 2 hours of sleep (p=0.02) and during hours 4 and 6 (p=0.01). Conclusion: Our study provides evidence for quantitative EEG changes, which precede the onset of cognitive decline and the diagnosis of dementia in elderly women. Whether the observed differences are functionally related to neurodegenerative changes or represent unspecific EEG alterations remains to be investigated. Support (if any) NIH grant # K23HL103850 (ID)

Item URL in elib:https://elib.dlr.de/94981/
Document Type:Conference or Workshop Item (Speech)
Additional Information:Volume 37, 2014 Abstract Supplement
Title:Associations between Quantitative Sleep EEG Data and Subsequent Cognitive Decline in Community-Dwelling Older Women
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Djonlagic, I.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Litwack Harrison, S.UNSPECIFIEDUNSPECIFIED
Dean, D.UNSPECIFIEDUNSPECIFIED
Yaffe, K.UNSPECIFIEDUNSPECIFIED
Ancoli-Israel, SoniaUNSPECIFIEDUNSPECIFIED
Stone, KatieUNSPECIFIEDUNSPECIFIED
Redline, S.UNSPECIFIEDUNSPECIFIED
Date:2014
Journal or Publication Title:Journal of Sleep and Sleep Disorders Research
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Page Range:A339
Series Name:Sleep
ISSN:0161-8105
Status:Published
Keywords:Quantitative EEG, Cognitive Performance, Aging
Event Title:28th Annual Meeting of the Associated Professional Sleep Societies, LLC
Event Location:Minneapolis, USA
Event Type:international Conference
Event Dates:31.05.-01.06.14
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Flight Physiology
Deposited By: Martin, Sophie
Deposited On:03 Feb 2015 08:14
Last Modified:31 Jul 2019 19:51

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