elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Effects of an artificial gravity countermeasure on orthostatic tolerance, blood volumes and aerobic power after short-term bed rest

Linnarsson, Dag and Hughson, R. L. and Fraser, K. S. and Clément, Gilles and Karlsson, L. and Mulder, Edwin and Paloski, William and Rittweger, Jörn and Wuyts, F.L. and Zange, Jochen (2015) Effects of an artificial gravity countermeasure on orthostatic tolerance, blood volumes and aerobic power after short-term bed rest. Journal of Applied Physiology, 118 (1), pp. 29-35. American Physiological Society. DOI: 10.1152/japplphysiol.00061.2014. ISSN 8750-7587

Full text not available from this repository.

Abstract

Exposure to artificial gravity (AG) in a short-arm centrifuge has potential benefits for maintaining human performance during long-term space missions. Eleven subjects were investigated during three campaigns of 5 days head-down bed rest: 1) bed rest without countermeasures (control), 2) bed rest and 30 min of AG (AG1) daily, and 3) bed rest and six periods of 5 min AG (AG2) daily. During centrifugation, the supine subjects were exposed to AG in the head-to-feet direction with 1 G at the center of mass. Subjects participated in the three campaigns in random order. The cardiovascular effects of bed rest and countermeasures were determined from changes in tolerance to a head-up tilt test with superimposed lower body negative pressure (HUT), from changes in plasma volume (PV) and from changes in maximum aerobic power (VO2 peak) during upright work on a cycle ergometer. Complete data sets were obtained in eight subjects. After bed rest, HUT tolerance times were 36, 64, and 78% of pre-bed rest baseline during control, AG1 and AG2, respectively, with a significant difference between AG2 and control. PV and V̇o2 peak decreased to 85 and 95% of pre-bed rest baseline, respectively, with no differences between the treatments. It was concluded that the AG2 countermeasure should be further investigated during future long-term bed rest studies, especially as it was better tolerated than AG1. The superior effect of AG2 on orthostatic tolerance could not be related to concomitant changes in PV or aerobic power.

Item URL in elib:https://elib.dlr.de/94696/
Document Type:Article
Title:Effects of an artificial gravity countermeasure on orthostatic tolerance, blood volumes and aerobic power after short-term bed rest
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Linnarsson, DagKarolinska Institutet, Dept. of Physiology and Pharmacology, Sect. of Environmental PhysiologyUNSPECIFIED
Hughson, R. L.Schlegel-University of WaterlooUNSPECIFIED
Fraser, K. S.Schlegel-University of Waterloo Research Institute for Aging, Faculty of Applied Health Sciences, University of Waterloo, CanadaUNSPECIFIED
Clément, GillesInternational Space University, Strasbourg, France, EUUNSPECIFIED
Karlsson, L.Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, SwedenUNSPECIFIED
Mulder, EdwinGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Paloski, WilliamNASA JSC, HoustonUNSPECIFIED
Rittweger, JörnInstitute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Wuyts, F.L.UNSPECIFIEDUNSPECIFIED
Zange, Jochenjochen.zange (at) dlr.deUNSPECIFIED
Date:January 2015
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:118
DOI :10.1152/japplphysiol.00061.2014.
Page Range:pp. 29-35
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:head-down tilt; head-up tilt; intermittent; lower body negative pressure; short-arm centrifuge
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:20 Jan 2015 10:12
Last Modified:06 Sep 2019 15:27

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.