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Changes in corticospinal transmission following 8 weeks of ankle joint immobilization

Leukel, Christian and Taube, Wolfgang and Rittweger, Jörn and Gollhofer, Albert and Ducos, Michel and Weber, Tobias and Lundbye-Jensen, Jesper (2015) Changes in corticospinal transmission following 8 weeks of ankle joint immobilization. Clinical Neurophysiology, 126 (1), pp. 131-139. Elsevier. DOI: 10.1016/j.clinph.2014.04.002 ISSN 1388-2457

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1016/j.clinph.2014.04.002

Abstract

OBJECTIVES: Joint immobilization has previously been shown to modulate corticospinal excitability. The present study investigated changes in the excitability of distinct fractions of the corticospinal pathway by means of conditioning the H-reflex with transcranial magnetic stimulation (TMS) of the primary motor cortex (Hcond). This method allows assessment of transmission in fast (monosynaptic) and slow(er) (polysynaptic) corticospinal pathways. METHODS: 9 subjects underwent 8weeks of unilateral ankle joint immobilization during daytime, 7 subjects served as controls. The measures obtained before and after immobilization included stretch- and H-reflexes assessing excitability of the spinal reflex circuitries, TMS recruitment curves estimating overall changes in corticospinal excitability, and Hcond. RESULTS: TMS recruitment curves showed an overall increase in corticospinal excitability following immobilization. Importantly, Hcond revealed significant facilitation of conditioned reflexes, but only for longer conditioning intervals, suggesting that immobilization increased excitability only of slower, indirect corticospinal pathways. No changes were observed in the control group. Immobilization had no significant effects on spinal reflex measures. CONCLUSIONS: 8weeks of ankle joint immobilization was accompanied by pathway-specific modulation of corticospinal transmission. SIGNIFICANCE: It is particularly interesting that fast corticospinal projections were unaffected as these are involved in controlling many, if not most, movements in humans.

Item URL in elib:https://elib.dlr.de/94694/
Document Type:Article
Title:Changes in corticospinal transmission following 8 weeks of ankle joint immobilization
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Leukel, ChristianDepartment of Medicine, Movement and Sport Science, University of Fribourg, SwitzerlandUNSPECIFIED
Taube, WolfgangDepartment of Medicine, Movement and Sport Science, University of Fribourg, SwitzerlandUNSPECIFIED
Rittweger, JörnInstitute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Gollhofer, AlbertDepartment of Sport Science, University of Freiburg, GermanyUNSPECIFIED
Ducos, MichelGerman Aerospace Centre, Institute of Aerospace Medicine, Division Space Physiology, Cologne, GermanyUNSPECIFIED
Weber, TobiasGerman Aerospace Centre, Institute of Aerospace Medicine, Division Space Physiology, Cologne, GermanyUNSPECIFIED
Lundbye-Jensen, JesperDepartment of Nutrition, Exercise and Sports, University of Copenhagen, DenmarkUNSPECIFIED
Date:January 2015
Journal or Publication Title:Clinical Neurophysiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:126
DOI :10.1016/j.clinph.2014.04.002
Page Range:pp. 131-139
Publisher:Elsevier
ISSN:1388-2457
Status:Published
Keywords:H-reflex conditioning; MEP recruitment; Motor evoked potential; Primary motor cortex; Spinal cord; Transcranial magnetic stimulation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:07 Jan 2016 16:29
Last Modified:08 Mar 2018 18:37

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