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Imaging of the Muscle-Bone Relationship

Ireland, Alex and Ferretti, José Luis and Rittweger, Jörn (2014) Imaging of the Muscle-Bone Relationship. Current Osteoporosis Reports, 12 (4), pp. 486-495. Springer. doi: 10.1007/s11914-014-0216-1. ISSN 1544-1873.

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Muscle can be assessed by imaging techniques according to its size (as thickness, area, volume, or alternatively, as a mass) and architecture (fiber length and pennation angle), with values used as an anthropometric measure or a surrogate for force production. Similarly, the size of the bone (as area or volume) can be imaged using MRI or pQCT, although typically bone mineral mass is reported. Bone imaging measures of mineral density, size, and geometry can also be combined to calculate bone’s structural strength—measures being highly predictive of bone’s failure load ex vivo. Imaging of muscle-bone relationships can, hence, be accomplished through a number of approaches by adoption and comparison of these different muscle and bone parameters, dependent on the research question under investigation. These approaches have revealed evidence of direct, mechanical muscle-bone interactions independent of allometric associations. They have led to important information on bone mechanoadaptation and the influence of muscular action on bone, in addition to influences of age, gender, exercise, and disuse on muscle-bone relationships. Such analyses have also produced promising diagnostic tools for clinical use, such as identification of primary, disuse-induced, and secondary osteoporosis and estimation of bone safety factors. Standardization of muscle-bone imaging methods is required to permit more reliable comparisons between studies and differing imaging modes, and in particular to aid adoption of these methods into widespread clinical practice.

Item URL in elib:https://elib.dlr.de/91853/
Document Type:Article
Title:Imaging of the Muscle-Bone Relationship
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Ireland, AlexManchester Metropolitan University, a.ireland (at) mmu.ac.ukUNSPECIFIED
Ferretti, José Luisjlferretti (at) arnet.com.arUNSPECIFIED
Rittweger, JörnInstitute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Date:September 2014
Journal or Publication Title:Current Osteoporosis Reports
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
DOI :10.1007/s11914-014-0216-1
Page Range:pp. 486-495
EditorsEmailEditor's ORCID iD
Keywords:Muscle, Bone, Imaging, BMD, DEXA, pQCT
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:18 Nov 2014 13:09
Last Modified:08 Mar 2018 18:36

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