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Further Aspects for the Foundation of A Conceptual Framework for Systems Life Science Under Space Conditions

Duwe, Helmut and Hoehn, Alexander and Thomas, Hubertus and Grès, Stéphane and Schuber, Marianne (2014) Further Aspects for the Foundation of A Conceptual Framework for Systems Life Science Under Space Conditions. In: SpacEarth - 6th International Congress of Medicine in Space and Extreme Environments. SpacEarth - 6th International Congress of Medicine in Space and Extreme Environments 2014, 16. - 19. Sept. 2014, Berlin, Germany.

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Official URL: http://www.charite-in-space.de/icms/conference-proceedings

Abstract

A strong impetus for the elaboration of a conceptual framework for integrative research under space conditions is clearly noticeable. A group of space-experienced investigators forwarded explicitly a request to the scientific community for such a conceptual framework [Goswami et al., 2012]. The EU funded THESEUS project (Towards Human Exploration of Space: a EUropean Strategy, http://www.theseus-eu.org/home.html) favors integrated physiology. A central method for setting up a conceptual framework is basically the elaboration of an integrated set of terms (concepts) and developing tools (like a markup language-based system) to implement the term set. The approach of Andrew McCulloch et al. [Hunter et al, 2006] for human physiology with six levels for multi-level integration (from the gene to the whole human body level) is extended here by two additional levels. For human physiology research in the context of space exploitation, first at all, a further level beyond the whole human body level is required, namely a human - environment level. Furthermore, arguments for a division of the molecular level into a molecular and an atomic level are put forward, e.g. for discussing electron configurations of free radicals. Essential terms of system theory (subsystem, structure, function, process, system environment, etc.) are introduced, complementing the main terms LEVEL and SCALE to comprise core elements of the framework proposal. The advancement reported is centered round a more rigorous definition of the term LEVEL, derived from an understanding of the system of interest (e.g. a bone cell) and setting levels via an embedded hierarchy of systems/subsystems. However, the full-flagged elaboration of a conceptual framework has to be organized as community-led, open project, similar to the way topical ontology groups are organized (compare with the approach of the Environment Ontology group, www.environmentontology.org).So far, the proposed core set of elements for the requested conceptual framework are exemplified with applications cases (e.g. space habitats and algae phenols, the world of picoNewtons in the microenvironment of osteocytes, unpaired electrons and the effects of free radicals for microbe control). The applications cases are interlinked with a recurrent theme: reactive species and antioxidants. A new relationship between hypothesis- (theory- and model-) driven und data-driven research is seen in the way that an iterative evolutionary alignment is needed, especially in the context of the rising importance of high throughput omics, combinatory screening, data-mining and meta-analysis.

Item URL in elib:https://elib.dlr.de/91717/
Document Type:Conference or Workshop Item (Poster)
Title:Further Aspects for the Foundation of A Conceptual Framework for Systems Life Science Under Space Conditions
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Duwe, HelmutDLR-Institute of Aerospace Medicine, Biomedical Research Group, Cologne, GermanyUNSPECIFIED
Hoehn, AlexanderTechnical University of Munich, Institute of Astronautics, Munich, GermanyUNSPECIFIED
Thomas, HubertusDLR Research Group Complex Plasma, OberpfaffenhofenUNSPECIFIED
Grès, StéphaneARTSEM / UTC– COSTECH, Compiegne, FranceUNSPECIFIED
Schuber, MarianneDLR Institute of Aerospace Medicine, Biomedical Research Group, Cologne, GermanyUNSPECIFIED
Date:16 September 2014
Journal or Publication Title:SpacEarth - 6th International Congress of Medicine in Space and Extreme Environments
Refereed publication:No
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Editors:
EditorsEmail
Stahn, AlexanderCenter for Space Medicine and Extreme Environments
Status:Published
Keywords:systems life science, conceptual framework, research under space conditions, ontologies, modeling, system levels, scales
Event Title:SpacEarth - 6th International Congress of Medicine in Space and Extreme Environments 2014
Event Location:Berlin, Germany
Event Type:international Conference
Event Dates:16. - 19. Sept. 2014
Organizer:Charité Universitätsmedizin Berlin
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz , Oberpfaffenhofen
Institutes and Institutions:Institute of Aerospace Medicine > Biomedical Research
Research Group Complex Plasma > Research Group Complex Plasma
Deposited By: Duwe, Helmut
Deposited On:13 Nov 2014 11:15
Last Modified:31 Jul 2019 19:48

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