elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Impressum | Datenschutz | Kontakt | English
Schriftgröße: [-] Text [+]

Further Aspects for the Foundation of A Conceptual Framework for Systems Life Science Under Space Conditions

Duwe, Helmut und Hoehn, Alexander und Thomas, Hubertus und Grès, Stéphane und Schuber, Marianne (2014) Further Aspects for the Foundation of A Conceptual Framework for Systems Life Science Under Space Conditions. In: SpacEarth - 6th International Congress of Medicine in Space and Extreme Environments. SpacEarth - 6th International Congress of Medicine in Space and Extreme Environments 2014, 2014-09-16 - 2014-09-19, Berlin, Germany.

[img] PDF (Poster "Further Aspects - Conceptual Framework - System Life Science under Space Conditions)
916kB

Offizielle URL: http://www.charite-in-space.de/icms/conference-proceedings

Kurzfassung

A strong impetus for the elaboration of a conceptual framework for integrative research under space conditions is clearly noticeable. A group of space-experienced investigators forwarded explicitly a request to the scientific community for such a conceptual framework [Goswami et al., 2012]. The EU funded THESEUS project (Towards Human Exploration of Space: a EUropean Strategy, http://www.theseus-eu.org/home.html) favors integrated physiology. A central method for setting up a conceptual framework is basically the elaboration of an integrated set of terms (concepts) and developing tools (like a markup language-based system) to implement the term set. The approach of Andrew McCulloch et al. [Hunter et al, 2006] for human physiology with six levels for multi-level integration (from the gene to the whole human body level) is extended here by two additional levels. For human physiology research in the context of space exploitation, first at all, a further level beyond the whole human body level is required, namely a human - environment level. Furthermore, arguments for a division of the molecular level into a molecular and an atomic level are put forward, e.g. for discussing electron configurations of free radicals. Essential terms of system theory (subsystem, structure, function, process, system environment, etc.) are introduced, complementing the main terms LEVEL and SCALE to comprise core elements of the framework proposal. The advancement reported is centered round a more rigorous definition of the term LEVEL, derived from an understanding of the system of interest (e.g. a bone cell) and setting levels via an embedded hierarchy of systems/subsystems. However, the full-flagged elaboration of a conceptual framework has to be organized as community-led, open project, similar to the way topical ontology groups are organized (compare with the approach of the Environment Ontology group, www.environmentontology.org).So far, the proposed core set of elements for the requested conceptual framework are exemplified with applications cases (e.g. space habitats and algae phenols, the world of picoNewtons in the microenvironment of osteocytes, unpaired electrons and the effects of free radicals for microbe control). The applications cases are interlinked with a recurrent theme: reactive species and antioxidants. A new relationship between hypothesis- (theory- and model-) driven und data-driven research is seen in the way that an iterative evolutionary alignment is needed, especially in the context of the rising importance of high throughput omics, combinatory screening, data-mining and meta-analysis.

elib-URL des Eintrags:https://elib.dlr.de/91717/
Dokumentart:Konferenzbeitrag (Poster)
Titel:Further Aspects for the Foundation of A Conceptual Framework for Systems Life Science Under Space Conditions
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Duwe, HelmutDLR-Institute of Aerospace Medicine, Biomedical Research Group, Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Hoehn, AlexanderTechnical University of Munich, Institute of Astronautics, Munich, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Thomas, HubertusDLR Research Group Complex Plasma, OberpfaffenhofenNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Grès, StéphaneARTSEM / UTC– COSTECH, Compiegne, FranceNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Schuber, MarianneDLR Institute of Aerospace Medicine, Biomedical Research Group, Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:16 September 2014
Erschienen in:SpacEarth - 6th International Congress of Medicine in Space and Extreme Environments
Referierte Publikation:Nein
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Herausgeber:
HerausgeberInstitution und/oder E-Mail-Adresse der HerausgeberHerausgeber-ORCID-iDORCID Put Code
Stahn, AlexanderCenter for Space Medicine and Extreme EnvironmentsNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Status:veröffentlicht
Stichwörter:systems life science, conceptual framework, research under space conditions, ontologies, modeling, system levels, scales
Veranstaltungstitel:SpacEarth - 6th International Congress of Medicine in Space and Extreme Environments 2014
Veranstaltungsort:Berlin, Germany
Veranstaltungsart:internationale Konferenz
Veranstaltungsbeginn:16 September 2014
Veranstaltungsende:19 September 2014
Veranstalter :Charité Universitätsmedizin Berlin
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Biowissenschaftliche Nutzerunterstützung (alt)
Standort: Köln-Porz , Oberpfaffenhofen
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Biomedizinische Forschung
Forschungsgruppe Komplexe Plasmen > Forschungsgruppe Komplexe Plasmen
Hinterlegt von: Duwe, Helmut
Hinterlegt am:13 Nov 2014 11:15
Letzte Änderung:24 Apr 2024 19:57

Nur für Mitarbeiter des Archivs: Kontrollseite des Eintrags

Blättern
Suchen
Hilfe & Kontakt
Informationen
electronic library verwendet EPrints 3.3.12
Gestaltung Webseite und Datenbank: Copyright © Deutsches Zentrum für Luft- und Raumfahrt (DLR). Alle Rechte vorbehalten.