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How fast is recovery of impaired glucose tolerance after 21-day bed rest (NUC study) in healthy adults?

Heer, M. and Baecker, Natalie and Wnendt, S. and Fischer, Annelie and Biolo, Gianni and Frings-Meuthen, Petra (2014) How fast is recovery of impaired glucose tolerance after 21-day bed rest (NUC study) in healthy adults? The Scientific World Journal (2014). Hindawi Publishing Corporation. doi: 10.1155/2014/803083. ISSN 1537-744X.

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Aim. We hypothesized that 4 days of normal daily activity after 21 days of experimental bed rest (BR) will not reverse BR induced impaired glucose tolerance. Design. Glucose tolerance of seven male, healthy, untrained test subjects (age: 27.6 (3.3) years (mean (SD)); body mass: 78.6 (6.4) kg; height: 1.81 (0.04) m; VO₂ max: 39.5 (5.4) ml/kg body mass/min) was studied. They stayed twice in the metabolic ward (crossover design), 21 days in bed and 7 days before and after BR each. Oral glucose tolerance tests were applied before, on day 21 of BR, and 5 and 14 days after BR. Results. On day 21 of BR, AUC120 min of glucose concentration was increased by 28.8 (5.2)% and AUC120 min of insulin by 35.9 (10.2)% (glucose: ; insulin: ). Fourteen days after BR, AUC120 min of serum insulin concentrations returned to pre-bed-rest concentrations () and AUC120 min of glucose was still higher (). Insulin resistance did not change, but sensitivity index was reduced during BR (). Conclusion. Four days of light physical workload does not compensate inactivity induced impaired glucose tolerance. An individually tailored and intensified training regime is mandatory in patients being in bed rest to get back to normal glucose metabolism in a reasonable time frame.

Item URL in elib:https://elib.dlr.de/90403/
Document Type:Article
Title:How fast is recovery of impaired glucose tolerance after 21-day bed rest (NUC study) in healthy adults?
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Heer, M.Institut für Ernährungswissenschaft, Universität Bonn, GermanyUNSPECIFIED
Baecker, NatalieInstitut für Ernährungswissenschaft, Universität Bonn, GermanyUNSPECIFIED
Wnendt, S.MLM Medical Labs GmbH, 41066 Monchengladbach, GermanyUNSPECIFIED
Fischer, AnnelieProfil Neuss GmbH, 41460 Neuss, GermanyUNSPECIFIED
Biolo, GianniDepartment of Clinical, Technological and Morphological Sciences, Division of Internal Medicine, University Triest, ItalienUNSPECIFIED
Frings-Meuthen, PetraGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Date:11 March 2014
Journal or Publication Title:The Scientific World Journal
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:No
DOI :10.1155/2014/803083
EditorsEmailEditor's ORCID iD
Publisher:Hindawi Publishing Corporation
Keywords:Glucose Tolerance, Recovery, bed rest
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:02 Sep 2014 12:35
Last Modified:24 Jun 2015 03:03

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