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Bone loss patterns in cortical, subcortical and trabecular compartments during simulated microgravity

Cervinka, Tomas and Sievänen, Harrir and Hyttinen, Jari and Rittweger, Jörn (2014) Bone loss patterns in cortical, subcortical and trabecular compartments during simulated microgravity. Journal of Applied Physiology, 117, pp. 80-88. American Physiological Society. DOI: 10.1152/japplphysiol.00021.2014 ISSN 8750-7587

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Official URL: http://www.jappl.org

Abstract

Disuse studies provide a useful model for bone adaptation. A direct comparison of these studies is, however, complicated by the different settings used for bone analysis. Through pooling and reanalysis of bone data from previous disuse studies, we determined bone loss and recovery in cortical, subcortical, and trabecular compartments and evaluated whether the study design modulated skeletal adaptation. Peripheral quantitative tomographic (pQCT) images from control groups of four disuse studies with a duration of 24, 35, 56, and 90 days were reanalyzed using a robust threshold-free segmentation algorithm. The pQCT data were available from 27 young healthy men at baseline, and at specified intervals over disuse and reambulation phases. The mean maximum absolute bone loss (mean +- 95% CI) was 6.1 +- 4.5 mg/mm in cortical, 2.4 +- 1.6 mg/mm in subcortical, and 9.8 +- 9.1 mg/mm in trabecular compartments, after 90 days of bed rest. The percentage changes in all bone compartments were, however, similar. During the first few weeks after onset of reambulation, the bone loss rate was systematically greater in the cortical than in the trabecular compartment (P < 0.002), and this was observed in all studies except for the longest study. We conclude that disuse-induced bone losses follow similar patterns irrespective of study design, and the largest mean absolute bone loss occurs in the cortical compartment, but apparently only during the first 60 days. With longer study duration, trabecular loss may become more prominent.

Item URL in elib:https://elib.dlr.de/90302/
Document Type:Article
Title:Bone loss patterns in cortical, subcortical and trabecular compartments during simulated microgravity
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Cervinka, TomasTampere University of TechnologyUNSPECIFIED
Sievänen, HarrirUKK InstituteUNSPECIFIED
Hyttinen, JariTampere University of TechnologyUNSPECIFIED
Rittweger, JörnInstitute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Date:8 May 2014
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:117
DOI :10.1152/japplphysiol.00021.2014
Page Range:pp. 80-88
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:bed rest; immobilization; osteoporosis; pQCT; image processing
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Beschleunigungsinduzierte Effekte (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:26 Aug 2014 12:04
Last Modified:06 Sep 2019 15:27

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