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Imaging muscle-bone relationships - how to see the invisible

Rittweger, Jörn and Ferretti, Jose Luis (2014) Imaging muscle-bone relationships - how to see the invisible. Clinical Reviews in Bone and Mineral Metabolism, 12 (1). Springer. doi: 10.1007/s12018-014-9166-5. ISSN 1534-8644.

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The ontogenetic adaptation of bones to their habitual loads offers a rationale for imaging muscle–bone relationships. Provided that bones adapt to strains that are chiefly determined by muscle contractions, information from muscle and bone scans allows comparing measures of bone stiffness and strength with surrogate measures for muscular force generation. Prediction of the mechanical behavior of bone is nowadays well possible by peripheral quantitative computed tomography (pQCT). However, prediction of muscle forces is not currently feasible. pQCT offers the opportunity to outline gross muscle cross-sectional area (CSA) as a surrogate measure of the forcegenerating capacity of muscle groups. Ultrasound and magnetic resonance (MR) imaging allow identification of single muscles. In addition, ultrasound also offers the possibility to assess muscle architecture and thus to assess physiological CSA as a more likely predictor of muscle forces than anatomical CSA. Although there is currently no single technique in use to simultaneously assess muscle volume, CSA, and architecture at the level of single muscles, this could in future be possible by MR diffusion imaging. Current attempts to quantify muscle ‘‘quality’’ are not directly related to the force-generating capacity and thus only of indirect help. Hence, one should hope that better imaging assessments of muscle will be possible in future. However, despite these current limitations, muscle– bone strength indicators have been defined that can already be used today in order to differentiate primary and secondary bone disorders thus underlining the validity of the ‘‘muscle–bone’’ approach.

Item URL in elib:https://elib.dlr.de/89133/
Document Type:Article
Title:Imaging muscle-bone relationships - how to see the invisible
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Rittweger, JörnInstitute of Aerospace Medicine, German Aerospace Center, joern.rittweger (at) dlr.deUNSPECIFIED
Ferretti, Jose LuisCenter of P-Ca Metabolism Studies (CEMFoC), jlferretti (at) arnet.com.arUNSPECIFIED
Date:4 April 2014
Journal or Publication Title:Clinical Reviews in Bone and Mineral Metabolism
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
DOI :10.1007/s12018-014-9166-5
Keywords:Mechano-adaptation, Mechanostat, Bone disorders, Muscle disorders
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:28 Oct 2014 12:19
Last Modified:14 Dec 2019 04:22

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