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Imaging Mechanical Muscle - Bone Relationships: How to See the Invisible

Rittweger, Jörn und Ferretti, Jose Luis (2014) Imaging Mechanical Muscle - Bone Relationships: How to See the Invisible. Clinical Reviews in Bone and Mineral Metabolism, 12 (1). Springer. doi: 10.1007/s12018-014-9166-5. ISSN 1534-8644.

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Kurzfassung

The ontogenetic adaptation of bones to their habitual loads offers a rationale for imaging muscle–bone relationships. Provided that bones adapt to strains that are chiefly determined by muscle contractions, information from muscle and bone scans allows comparing measures of bone stiffness and strength with surrogate measures for muscular force generation. Prediction of the mechanical behavior of bone is nowadays well possible by peripheral quantitative computed tomography (pQCT). However, prediction of muscle forces is not currently feasible. pQCT offers the opportunity to outline gross muscle cross-sectional area (CSA) as a surrogate measure of the forcegenerating capacity of muscle groups. Ultrasound and magnetic resonance (MR) imaging allow identification of single muscles. In addition, ultrasound also offers the possibility to assess muscle architecture and thus to assess physiological CSA as a more likely predictor of muscle forces than anatomical CSA. Although there is currently no single technique in use to simultaneously assess muscle volume, CSA, and architecture at the level of single muscles, this could in future be possible by MR diffusion imaging. Current attempts to quantify muscle ‘‘quality’’ are not directly related to the force-generating capacity and thus only of indirect help. Hence, one should hope that better imaging assessments of muscle will be possible in future. However, despite these current limitations, muscle– bone strength indicators have been defined that can already be used today in order to differentiate primary and secondary bone disorders thus underlining the validity of the ‘‘muscle–bone’’ approach.

elib-URL des Eintrags:https://elib.dlr.de/89133/
Dokumentart:Zeitschriftenbeitrag
Titel:Imaging Mechanical Muscle - Bone Relationships: How to See the Invisible
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Rittweger, JörnInstitute of Aerospace Medicine, German Aerospace Center, joern.rittweger (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Ferretti, Jose LuisCenter of P-Ca Metabolism Studies (CEMFoC), jlferretti (at) arnet.com.arNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:4 April 2014
Erschienen in:Clinical Reviews in Bone and Mineral Metabolism
Referierte Publikation:Ja
Open Access:Nein
Gold Open Access:Nein
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:12
DOI:10.1007/s12018-014-9166-5
Verlag:Springer
ISSN:1534-8644
Status:veröffentlicht
Stichwörter:Mechano-adaptation, Mechanostat, Bone disorders, Muscle disorders
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Becker, Christine
Hinterlegt am:28 Okt 2014 12:19
Letzte Änderung:21 Nov 2023 11:30

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