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Bone metabolic responses to bed rest in young and older men

Rittweger, Jörn and Bühlmeier, Judith and Frings-Meuthen, Petra and Mohorko, N and Pisot, Rado and Simunic, Bostjan (2014) Bone metabolic responses to bed rest in young and older men. John Wiley & Sons ltd..

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Official URL: http://www.actaphysiol.org

Abstract

It is well known that immobilization, through reduction of musculoskeletal forces, leads to bone loss. This is well established for clinical conditions, such as stroke, spinal cord injury as well as for spaceflight and disuse models, such as experimental bed rest. Age is another condition that predisposes to bone loss, which is intimately linked to fractures in the elderly population. Bone turn-over is known to be reduced in the elderly, and animal studies suggest ablunted response of bont to mechanical stimuli at old age, and that old age might 'shield' against immobilization-reduced bone loss. Whether this applies also to humans is currently unknown. The aim of the present study therefore was to compare bone metabolic responses to bed rest in a group of young (23.4 (SD2.9) Years, n=7) and older men (59.1 (SD 2.5) Years, n=8). It was hypothesized that bone metabolic responeses would be generally blunted in older men.

Item URL in elib:https://elib.dlr.de/88539/
Document Type:Proceedings
Title:Bone metabolic responses to bed rest in young and older men
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Bühlmeier, JudithUniversity of BonnUNSPECIFIED
Frings-Meuthen, PetraMEUNSPECIFIED
Mohorko, NUniversity of PrimorskaUNSPECIFIED
Pisot, RadoUniversity of PrimorskaUNSPECIFIED
Simunic, BostjanUniversity of PrimorskaUNSPECIFIED
Date:March 2014
Refereed publication:No
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Volume:210
Number of Pages:1
Publisher:John Wiley & Sons ltd.
Status:Published
Keywords:Bone metabolic, bed rest, young men, older men
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:other
DLR - Research area:Raumfahrt
DLR - Program:R - no assignment
DLR - Research theme (Project):R - no assignment
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:18 Mar 2014 17:22
Last Modified:31 Jul 2019 19:45

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