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The pQCT “Bone Strength Indices” (BSIs, SSI). Relative mechanical impact and diagnostic value of the indicators of bone tissue and design quality employed in their calculation in healthy men and pre- and post-menopausal women

Cointry, Gustavo and Ferretti, Jose Luis and Reina, P. S. and Nocciolono, L. M. and Rittweger, Jörn and Capozza, R. F. (2014) The pQCT “Bone Strength Indices” (BSIs, SSI). Relative mechanical impact and diagnostic value of the indicators of bone tissue and design quality employed in their calculation in healthy men and pre- and post-menopausal women. Journal of Musculoskeletal and Neuronal Interactions, 14 (1), pp. 29-40. International Society of Musculoskeletal and Neuronal Interactions. ISSN 1108-7161

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Official URL: http://www.ismni.org/jmni/index.htm

Abstract

The pQCT-assessed Bone Strength Indices (BSI’s, SSI) depend on the product of a “quality” indicator, the cortical vBMD (vCtD), and a “design” indicator, one of the cross-sectional moments of inertia or related variables (MIs) in long bones. As the MIs vary naturally much more than the vCtD and represent different properties, it could be that the variation of the indices might not reflect the relative mechanical impact of the variation of their determinant factors in different individuals or circumstances. To understand this problem, we determined the vCtD and MI’s in tibia scans of 232 healthy men and pre- and post-MP women, expressed in SD of the means calculated for each group, and analyzed the independent influence of 1 SD unit of variation of each factor on that of the indices by multiple correlations. Results showed: 1. that the independent influence of the MIs on the indices was generally larger than that of the vCtD, and 2. that in post-MP women the influence of the vCtD was larger than it was in the other groups. This confirms the view that inter-individual variation of vCtD is comparatively small, and that mechanical competence of human bone is mostly determined by ‘design’ factors.

Item URL in elib:https://elib.dlr.de/88489/
Document Type:Article
Title:The pQCT “Bone Strength Indices” (BSIs, SSI). Relative mechanical impact and diagnostic value of the indicators of bone tissue and design quality employed in their calculation in healthy men and pre- and post-menopausal women
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Cointry, GustavoNational University of RosarioUNSPECIFIED
Ferretti, Jose Luisjlferretti (at) arnet.com.arUNSPECIFIED
Reina, P. S.CEMFoCUNSPECIFIED
Nocciolono, L. M.CEMFoCUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Capozza, R. F.CEMFoCUNSPECIFIED
Date:March 2014
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:14
Page Range:pp. 29-40
Publisher:International Society of Musculoskeletal and Neuronal Interactions
ISSN:1108-7161
Status:Published
Keywords:Bone Structure, Bone Biomechanics, Moment of Inertia, Bone Density, Bone Quality, pQCT, Bone Strenght Index, Bone Strength Evaluation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):Vorhaben Knocheneigenschaften
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:12 Mar 2014 12:37
Last Modified:30 Aug 2017 10:16

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