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Elevated serumsoluble CD200 and CD200R as surrogatemarkers of bone loss under bed rest conditions

Kos, O. and Hughson, R. L. and Hart, D. A. and Clément, Gilles and Frings-Meuthen, Petra and Linnarsson, Dag and Paloski, William and Rittweger, Jörn and Wuyts, F.L. and Zange, J. and Gorczynski, R. M. (2014) Elevated serumsoluble CD200 and CD200R as surrogatemarkers of bone loss under bed rest conditions. Bone, 60, pp. 33-40. Elsevier. DOI: 10.1016/j.bone.2013.12.004 ISSN 8756-3282

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Official URL: http://www.elsevier.com/locate/bone

Abstract

CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types. Upon interaction with its receptors (CD200Rs) expressed on myeloidderived cells and T lymphocytes, an immunoregulatory signal is delivered to receptor-expressing cells. Previous studies have implicated a role for CD200:CD200R in the regulation of the expression of mRNA markers of osteoclastogenesis/osteoblastogenesis, following interaction of CD200 (on osteoblast precursors) with CD200R1 (on osteoclast precursors). Signaling of CD200R1 is hypothesized to attenuate osteoclastogenesis. Wehave investigatedwhether levels of soluble forms of CD200 and/or CD200R1 (sCD200, sCD200R1) are altered in volunteers undergoing 6° head down tilt bed rest tomimic conditions of microgravity known to be associated with preferential osteoclastogenesis and whether countermeasures, reported to be beneficial in attenuation of bone loss under microgravity conditions, would lead to altered sCD200 and sCD200R1 levels. Our data suggest that, as predicted, sCD200 levels fall under bed rest conditionswhile sCD200R1 levels rise. In subjects undergoing 30-minute per day continuous centrifugation protocols, as a countermeasure to attenuate changes which may lead to bone loss, these alterations in sCD200 and sCD200R1 levels seen under conditions of bed rest were abolished or attenuated. Our results suggest that measurement of sCD200 and/or sCD200R1 may prove a useful and rapid means of monitoring subjects at risk of bone loss and/or accessing the efficacy of treatment regimes designed to counter bone loss.

Item URL in elib:https://elib.dlr.de/88438/
Document Type:Article
Title:Elevated serumsoluble CD200 and CD200R as surrogatemarkers of bone loss under bed rest conditions
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Kos, O.Toronto Hospital and University Health NetworkUNSPECIFIED
Hughson, R. L.Schlegel-University of WaterlooUNSPECIFIED
Hart, D. A.McCaig Institute for Bone & Joint HealthUNSPECIFIED
Clément, GillesInternational Space University, Strasbourg, France, EUUNSPECIFIED
Frings-Meuthen, PetraMEUNSPECIFIED
Linnarsson, DagKarolinska Institutet, Dep. of Physiology and Pharmacology, Sect. of Environmental Physiology, Stockholm, SwedenUNSPECIFIED
Paloski, WilliamUniversity of HoustonUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Wuyts, F.L.UNSPECIFIEDUNSPECIFIED
Zange, J.UNSPECIFIEDUNSPECIFIED
Gorczynski, R. M.Transplant Research DivisionUNSPECIFIED
Date:March 2014
Journal or Publication Title:Bone
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:60
DOI :10.1016/j.bone.2013.12.004
Page Range:pp. 33-40
Editors:
EditorsEmail
Burr, DavidUNSPECIFIED
Publisher:Elsevier
ISSN:8756-3282
Status:Published
Keywords:Bed rest Study; CD200; CD200R; Artificial gravity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Effects of Mikro-g und Hyper-g
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:05 Mar 2014 12:41
Last Modified:10 Jan 2019 15:46

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