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The relationship between brain cortical activity and brain oxygenation in the prefrontal cortex during hypergravity exposure

Smith, Craig and Goswami, Nandu and Robinson, Ryan and von der Wiesche, Melanie and Schneider, Stefan (2013) The relationship between brain cortical activity and brain oxygenation in the prefrontal cortex during hypergravity exposure. Journal of Applied Physiology, 114, pp. 905-910. American Physiological Society. doi: 10.1152/japplphysiol.01426.2012. ISSN 8750-7587.

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Official URL: http://jap.physiology.org/content/early/2013/01/28/japplphysiol.01426.2012

Abstract

Artificial gravity has been proposed as a method to counteract the physiological de-conditioning of long duration spaceflight, however the effects of hypergravity on the central nervous system has had little study. The study aims to investigate whether there is a relationship between prefrontal cortex brain activity and prefrontal cortex oxygenation during exposure to hypergravity. Twelve healthy participants were selected to undergo hypergravity exposure aboard a Short Arm Human Centrifuge. Participants were exposed to hypergravity in the +Gz axis, starting from 0.6+Gz for females, and 0.8+Gz for males, gradually increasing by 0.1+Gz, until the participant showed signs of syncope. Brain cortical activity was measured using electroencephalography (EEG), and localized to the prefrontal cortex using standard low resolution brain electromagnetic tomography (LORETA). Prefrontal cortex oxygenation was measured using near-infrared spectroscopy (NIRS). A significant increase in prefrontal cortex activity (p < 0.05) was observed during hypergravity exposure compared to baseline. Prefrontal cortex oxygenation was significantly decreased during hypergravity exposure, with a decrease in oxyhemoglobin levels (p < 0.05) compared to baseline, and an increase in deoxyhemoglobin levels (p < 0.05) with increasing +Gz level. No significant correlation was found between prefrontal cortex activity and oxy/deoxyhemoglobin. It is concluded that the increase in prefrontal cortex activity observed during hypergravity was most likely not the result of increased +Gz values resulting in a decreased oxygenation produced through hypergravity exposure. No significant relationship between prefrontal cortex activity and oxygenation measured by NIRS, concludes brain activity during exposure to hypergravity may be difficult to measure using NIRS. Instead, the increased in prefrontal cortex activity might be attributable to psychological stress, which could pose a problem for the use of a SAHC as a countermeasure.

Item URL in elib:https://elib.dlr.de/87976/
Document Type:Article
Title:The relationship between brain cortical activity and brain oxygenation in the prefrontal cortex during hypergravity exposure
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Smith, CraigKing's College LondonUNSPECIFIED
Goswami, NanduInstitute of Physiology, Center of Physiological Medicine, Medical University of Graz, Graz, Austria, EUUNSPECIFIED
Robinson, RyanKing' College LondonUNSPECIFIED
von der Wiesche, MelanieGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, GermanyUNSPECIFIED
Schneider, StefanGerman Sport University Cologne, Institute of Movement and Neurosciences, Dep. of Exercise Neuroscience, Cologne, GermanyUNSPECIFIED
Date:April 2013
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:114
DOI :10.1152/japplphysiol.01426.2012
Page Range:pp. 905-910
Editors:
EditorsEmailEditor's ORCID iD
UNSPECIFIEDThe American Physiological SocietyUNSPECIFIED
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:Artificial Gravity; Hypergravity; EEG; NIRS; prefrontal cortex
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Artificial Gravity (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine
Deposited By: von der Wiesche, Dr.rer.nat. Melanie
Deposited On:04 Feb 2014 10:48
Last Modified:06 Sep 2019 15:27

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