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Thigh muscle volume in relation to age, sex and femur volume

Maden-Wilkinson, T. M. and McPhee, Jamie and Rittweger, Jörn and Jones, David A and Degens, Hans (2013) Thigh muscle volume in relation to age, sex and femur volume. AGE, 36, pp. 383-393. Springer. DOI: DOI 10.1007/s11357-013-9571-6 ISSN 0161-9152

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Abstract

Secular changes and intra-individual differences in body shape and size can confound crosssectional studies of muscle ageing. Normalising muscle mass to height squared is often suggested as a solution for this. We hypothesised that normalisation of muscle volume to femur volumemay be a better way of determining the extent of muscle lost with ageing (sarcopenia). Thigh and femur muscle volumes were measured from serial magnetic resonance imaging sections in 20 recreationally active young men (mean age 22.4 years), 25 older men (72.3 years), 18 young women (22.1 years) and 28 older women (72.0 years). There were no age-related differences in femur volume. The relationship between thigh muscle volume and femur volume (R2=0.76; exponent of 1.12; P<0.01) was stronger than that with height (R2=0.49; exponent of 3.86; P<0.01) in young participants. For young subjects, the mean muscle/bone ratios were 16.0 and 14.6 for men and women, respectively. For older men and women, the mean ratios were 11.6 and 11.5, respectively. The Z score for the thigh muscle/bone volume ratio relative to young subjects was −2.2±0.7 for older men and −1.4±0.8 for older women. The extent of sarcopenia judged by the muscle/bone ratio was approximately twice that determined when normalising to height squared. These data suggest that the muscle/bone ratio captures the intra-individual loss of muscle mass during ageing, and that the age-related loss of muscle mass may be underestimated when normalised to height squared. The quadriceps seems relatively more affected by ageing than other thigh muscles.

Item URL in elib:https://elib.dlr.de/87974/
Document Type:Article
Title:Thigh muscle volume in relation to age, sex and femur volume
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Maden-Wilkinson, T. M.Manchester Metropolitan UniversityUNSPECIFIED
McPhee, JamieManchester MetropolitanUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Jones, David AManchester Metropolitan UniversityUNSPECIFIED
Degens, HansManchester Metropolitan UniversityUNSPECIFIED
Date:2013
Journal or Publication Title:AGE
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:No
Volume:36
DOI :DOI 10.1007/s11357-013-9571-6
Page Range:pp. 383-393
Publisher:Springer
ISSN:0161-9152
Status:Published
Keywords:Muscle-to-bone ratio, Sarcopenia, Ageing
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:04 Feb 2014 08:55
Last Modified:06 Sep 2019 15:30

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