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Whole-Body Vibrations Do Not Elevate the Angiogenic Stimulus when Applied during Resistance Exercise

Beijer, Asa and Rosenberger, André and Bölck, Birgit and Suhr, Frank and Rittweger, Jörn and Bloch, W. (2013) Whole-Body Vibrations Do Not Elevate the Angiogenic Stimulus when Applied during Resistance Exercise. PLoS One, 8 (11), pp. 1-11. Public Library of Science (PLoS). doi: 10.1371/journal.pone.0080143. ISSN 1932-6203.

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Official URL: http://www.plosone.org


Knowledge about biological factors involved in exercise-induced angiogenesis is to date still scanty. The present study aimed to investigate the angiogenic stimulus of resistance exercise with and without superimposed whole-body vibrations. Responses to the exercise regimen before and after a 6-week training intervention were investigated in twenty-six healthy male subjects. Serum was collected at the initial and final exercise sessions and circulating levels of matrix metalloproteinases (MMP) -2 and -9, Vascular Endothelial Growth Factor (VEGF) and endostatin were determined via ELISA. Furthermore, we studied the proliferative effect of serum-treated human umbilical vein endothelial cells in vitro via BrdU-incorporation assay. It was found that circulating MMP-2, MMP-9, VEGF and endostatin levels were significantly elevated (P,0.001) from resting levels after both exercise interventions, with higher post-exercise VEGF concentrations in the resistance exercise (RE) group compared to the resistive vibration exercise (RVE) group. Moreover, RE provoked increased endothelial cell proliferation in vitro and higher post-exercise circulating endostatin concentrations after 6 weeks of training. These effects were elusive in the RVE group. The present findings suggest that resistance exercise leads to a transient rise in circulating angiogenic factors and superimposing vibrations to this exercise type might not further trigger a potential signaling of angiogenic stimulation in skeletal muscle.

Item URL in elib:https://elib.dlr.de/87971/
Document Type:Article
Title:Whole-Body Vibrations Do Not Elevate the Angiogenic Stimulus when Applied during Resistance Exercise
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Bölck, BirgitGerman Sport University CologneUNSPECIFIEDUNSPECIFIED
Suhr, FrankGerman Sport University CologneUNSPECIFIEDUNSPECIFIED
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Bloch, W.German Sport University CologneUNSPECIFIEDUNSPECIFIED
Date:15 November 2013
Journal or Publication Title:PLoS One
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:pp. 1-11
EditorsEmailEditor's ORCID iDORCID Put Code
Addison,, Christina LynnOttawa Hospital Research Institute, CanadaUNSPECIFIEDUNSPECIFIED
Publisher:Public Library of Science (PLoS)
Keywords:resistance Exercise, WBV, Blood Pressure, One-Repetition, Maximum, Training
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Effects of Mikro-g und Hyper-g (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:04 Feb 2014 08:54
Last Modified:29 Nov 2023 12:38

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