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Whole-Body Vibrations Do Not Elevate the Angiogenic Stimulus when Applied during Resistance Exercise

Beijer, Asa and Rosenberger, André and Bölck, Birgit and Suhr, Frank and Rittweger, Jörn and Bloch, W. (2013) Whole-Body Vibrations Do Not Elevate the Angiogenic Stimulus when Applied during Resistance Exercise. PLoS One, 8 (11), pp. 1-11. Public Library of Science (PLoS). DOI: 10.1371/journal.pone.0080143 ISSN 1932-6203

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Official URL: http://www.plosone.org

Abstract

Knowledge about biological factors involved in exercise-induced angiogenesis is to date still scanty. The present study aimed to investigate the angiogenic stimulus of resistance exercise with and without superimposed whole-body vibrations. Responses to the exercise regimen before and after a 6-week training intervention were investigated in twenty-six healthy male subjects. Serum was collected at the initial and final exercise sessions and circulating levels of matrix metalloproteinases (MMP) -2 and -9, Vascular Endothelial Growth Factor (VEGF) and endostatin were determined via ELISA. Furthermore, we studied the proliferative effect of serum-treated human umbilical vein endothelial cells in vitro via BrdU-incorporation assay. It was found that circulating MMP-2, MMP-9, VEGF and endostatin levels were significantly elevated (P,0.001) from resting levels after both exercise interventions, with higher post-exercise VEGF concentrations in the resistance exercise (RE) group compared to the resistive vibration exercise (RVE) group. Moreover, RE provoked increased endothelial cell proliferation in vitro and higher post-exercise circulating endostatin concentrations after 6 weeks of training. These effects were elusive in the RVE group. The present findings suggest that resistance exercise leads to a transient rise in circulating angiogenic factors and superimposing vibrations to this exercise type might not further trigger a potential signaling of angiogenic stimulation in skeletal muscle.

Item URL in elib:https://elib.dlr.de/87971/
Document Type:Article
Title:Whole-Body Vibrations Do Not Elevate the Angiogenic Stimulus when Applied during Resistance Exercise
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Beijer, Asaasa.beijer (at) dlr.deUNSPECIFIED
Rosenberger, Andréandre.rosenberger (at) dlr.deUNSPECIFIED
Bölck, BirgitGerman Sport University CologneUNSPECIFIED
Suhr, FrankGerman Sport University CologneUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Bloch, W.German Sport University CologneUNSPECIFIED
Date:15 November 2013
Journal or Publication Title:PLoS One
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:8
DOI :10.1371/journal.pone.0080143
Page Range:pp. 1-11
Editors:
EditorsEmail
Addison,, Christina LynnOttawa Hospital Research Institute, Canada
Publisher:Public Library of Science (PLoS)
ISSN:1932-6203
Status:Published
Keywords:resistance Exercise, WBV, Blood Pressure, One-Repetition, Maximum, Training
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Effects of Mikro-g und Hyper-g
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:04 Feb 2014 08:54
Last Modified:08 Mar 2018 18:49

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