Mendolia, F. and Klein, J.P. and Petersdorf, E.W. and Malkki, M. and Wang, T. (2013) Comparison of statistics in association tests of genetic markers for survival outcomes. Statistics in Medicine. Wiley. ISSN 0277-6715.
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Abstract
Computationally efficient statistical tests are needed in association testing of large scale genetic markers for survival outcomes. In this study, we explore several test statistics based on the Cox proportional hazards model for survival data. First, we consider the classical partial likelihood-based Wald and score tests. A revised way to compute the score statistics is explored to improve the computational efficiency. Next, we propose a Cox–Snell residual-based score test, which allows us to handle the controlling variables more conveniently. We also illustrated the incorporation of these three tests into a permutation procedure to adjust for the multiple testing. In addition, we examine a simulation-based approach proposed by Lin (2005) to adjust for multiple testing. We presented the comparison of these four statistics in terms of type I error, power, family-wise error rate, and computational efficiency under various scenarios via extensive simulation.
Item URL in elib: | https://elib.dlr.de/86484/ | ||||||||||||||||||
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Document Type: | Article | ||||||||||||||||||
Title: | Comparison of statistics in association tests of genetic markers for survival outcomes | ||||||||||||||||||
Authors: |
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Date: | 2013 | ||||||||||||||||||
Journal or Publication Title: | Statistics in Medicine | ||||||||||||||||||
Refereed publication: | Yes | ||||||||||||||||||
Open Access: | No | ||||||||||||||||||
Gold Open Access: | No | ||||||||||||||||||
In SCOPUS: | Yes | ||||||||||||||||||
In ISI Web of Science: | Yes | ||||||||||||||||||
Publisher: | Wiley | ||||||||||||||||||
ISSN: | 0277-6715 | ||||||||||||||||||
Status: | Published | ||||||||||||||||||
Keywords: | survival outcome; Cox proportional hazard model; Cox–Snell residuals; multiple testing; genetic markers | ||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | ||||||||||||||||||
HGF - Program: | Aeronautics | ||||||||||||||||||
HGF - Program Themes: | ATM and Operation (old) | ||||||||||||||||||
DLR - Research area: | Aeronautics | ||||||||||||||||||
DLR - Program: | L AO - Air Traffic Management and Operation | ||||||||||||||||||
DLR - Research theme (Project): | L - Human Factors and Safety in Aeronautics (old) | ||||||||||||||||||
Location: | Köln-Porz | ||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine > Flight Physiology | ||||||||||||||||||
Deposited By: | Sender, Alina | ||||||||||||||||||
Deposited On: | 20 Dec 2013 10:56 | ||||||||||||||||||
Last Modified: | 08 Mar 2018 18:33 |
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