Mendolia, F. und Klein, J.P. und Petersdorf, E.W. und Malkki, M. und Wang, T. (2013) Comparison of statistics in association tests of genetic markers for survival outcomes. Statistics in Medicine. Wiley. doi: 10.1002/sim.5982. ISSN 0277-6715.
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Kurzfassung
Computationally efficient statistical tests are needed in association testing of large scale genetic markers for survival outcomes. In this study, we explore several test statistics based on the Cox proportional hazards model for survival data. First, we consider the classical partial likelihood-based Wald and score tests. A revised way to compute the score statistics is explored to improve the computational efficiency. Next, we propose a Cox–Snell residual-based score test, which allows us to handle the controlling variables more conveniently. We also illustrated the incorporation of these three tests into a permutation procedure to adjust for the multiple testing. In addition, we examine a simulation-based approach proposed by Lin (2005) to adjust for multiple testing. We presented the comparison of these four statistics in terms of type I error, power, family-wise error rate, and computational efficiency under various scenarios via extensive simulation.
elib-URL des Eintrags: | https://elib.dlr.de/86484/ | ||||||||||||||||||||||||
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Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||||||
Titel: | Comparison of statistics in association tests of genetic markers for survival outcomes | ||||||||||||||||||||||||
Autoren: |
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Datum: | 2013 | ||||||||||||||||||||||||
Erschienen in: | Statistics in Medicine | ||||||||||||||||||||||||
Referierte Publikation: | Ja | ||||||||||||||||||||||||
Open Access: | Nein | ||||||||||||||||||||||||
Gold Open Access: | Nein | ||||||||||||||||||||||||
In SCOPUS: | Ja | ||||||||||||||||||||||||
In ISI Web of Science: | Ja | ||||||||||||||||||||||||
DOI: | 10.1002/sim.5982 | ||||||||||||||||||||||||
Verlag: | Wiley | ||||||||||||||||||||||||
ISSN: | 0277-6715 | ||||||||||||||||||||||||
Status: | veröffentlicht | ||||||||||||||||||||||||
Stichwörter: | survival outcome; Cox proportional hazard model; Cox–Snell residuals; multiple testing; genetic markers | ||||||||||||||||||||||||
HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||||||||||||||||||
HGF - Programm: | Luftfahrt | ||||||||||||||||||||||||
HGF - Programmthema: | ATM und Flugbetrieb (alt) | ||||||||||||||||||||||||
DLR - Schwerpunkt: | Luftfahrt | ||||||||||||||||||||||||
DLR - Forschungsgebiet: | L AO - Luftverkehrsmanagement und Flugbetrieb | ||||||||||||||||||||||||
DLR - Teilgebiet (Projekt, Vorhaben): | L - Faktor Mensch und Sicherheit in der Luftfahrt (alt) | ||||||||||||||||||||||||
Standort: | Köln-Porz | ||||||||||||||||||||||||
Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin > Flugphysiologie | ||||||||||||||||||||||||
Hinterlegt von: | Sender, Alina | ||||||||||||||||||||||||
Hinterlegt am: | 20 Dez 2013 10:56 | ||||||||||||||||||||||||
Letzte Änderung: | 15 Jun 2023 14:39 |
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