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Bone-like material based on aerogels

Ganesan, Kathirvel and Ratke, Lorenz and Bartsch, Marion and Mittag, Uwe and Rittweger, Jörn (2013) Bone-like material based on aerogels.  Jahres Tagung der Deutschen Gesellschaft für Biomaterialien 2013, 26.-28.09.2013, Erlangen, Germany.

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Abstract

Humans in space suffer loss of bone mass that weakens their bone. This is due to bone remodeling processes in the spongious bone areas under the disuse conditions in near zero gravity. On the way to a better understanding of those processes interdisciplinary expertise inside DLR has been pulled together to develop and apply numerical and physical simulation methods. In this context the typical open porous sponge structure of polysaccharide aerogel coated with the bone mineral calcium phosphate, i.e., aerogel composite can be used as model system for structural and mechanical behaviour of cancellous bone, with a later option of using it as biocompatible bone surrogate or scaffold material. Bone-like material based on aerogels can be synthesized by mineralizing inorganic component, calcium phosphate in organic matrix of polysaccharides. Aerogels of polysaccharides, e.g., cellulose, chitosan, chitin and κ-carrageenan were used as organic matrix in this study because of their nanofelt fibrillar structure, chelating functional groups, biocompatibility and biodegradability1. The macroporous sponge structures (50 to 200 µm) were produced by emulsion template method. Electron microscopic images showed meso- and macroporous structures with a fibre thickness of about 10 to 20 nm. Simulated body fluid was used to mineralize calcium phosphate nanocrystal in macroporous structure. Supercritical CO2 was used to dry the polysaccharide-calcium phosphate composite structure. The properties of aerogel composite such as density, mechanical strength can be tuned by varying the concentration and composition of the organic and inorganic parts. The preliminary results would be presented and discussed.

Item URL in elib:https://elib.dlr.de/85229/
Document Type:Conference or Workshop Item (Speech)
Title:Bone-like material based on aerogels
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Ganesan, Kathirvelk.ganesan (at) dlr.dehttps://orcid.org/0000-0002-4876-5366
Ratke, Lorenzlorenz.ratke (at) dlr.deUNSPECIFIED
Bartsch, Marionmarion.bartsch (at) dlr.deUNSPECIFIED
Mittag, Uweuwe.mittag (at) dlr.deUNSPECIFIED
Rittweger, Jörnjoern.rittweger (at) dlr.deUNSPECIFIED
Date:2013
Refereed publication:No
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Bone; Aerogel; Calcium; Phosphate.
Event Title: Jahres Tagung der Deutschen Gesellschaft für Biomaterialien 2013
Event Location:Erlangen, Germany
Event Type:national Conference
Event Dates:26.-28.09.2013
Organizer:Deutschen Gesellschaft für Biomaterialien
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Materialwissenschaftliche Forschung (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Materials Physics in Space
Deposited By: Ganesan, Dr. Kathirvel
Deposited On:12 Nov 2013 10:34
Last Modified:14 Jan 2019 07:54

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