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A refined Mechanostat Model of Bone Transformation

Mittag, Uwe and Kriechbaumer, Andreas and Bartsch, Marion and Rittweger, Joern (2013) A refined Mechanostat Model of Bone Transformation. A refined Mechanostat Model of Bone Transformation, 7.7.-12.Juli 2013, Köln, Deutschland. (Unpublished)

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Abstract

Bone is a living tissue that shows adaptation in shape and structure, if the prevailing load conditions are significantly changing. One example is the loss of bone mass of astronauts under microgravity, which can already be measured after missions of medium duration. Transformation laws derived from experimental data have been able to explain morphologic adaptation of the microstructure of trabecular bone to external loads. In the present work the focus is on the hypothesis, that the same transformation law is able to govern shape adaptation and adaptation of microstructure depending only on the different load pattern. This work is an effort to concile the famous phenomenologic mechanostat model of Frost [Frost 2000] with a mechanistic approach of Huiskes and his co-workers [Huiskes, 2000]. The present in-silico study has shown that the mechanostat scheme based on basic mechanistic principles can engender diverse load bearing structure depending on the different needs: the epiphysis collecting loads from different directions prefers trussy structure, the torsion and axial load bearing shaft prefers tubular structure. That is similar to the findings in bone with the difference, that the “trussy” structure in epiphysis is much finer, namely spongy. That seems to be a scaling problem to be analysed in the future.

Item URL in elib:https://elib.dlr.de/85077/
Document Type:Conference or Workshop Item (Poster)
Title:A refined Mechanostat Model of Bone Transformation
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Mittag, UweUwe.Mittag (at) dlr.deUNSPECIFIED
Kriechbaumer, AndreasAndreas.Kriechbaumer (at) dlr.deUNSPECIFIED
Bartsch, MarionMarion.Bartsch (at) dlr.deUNSPECIFIED
Rittweger, Joernjoern.rittweger (at) dlr.deUNSPECIFIED
Date:July 2013
Refereed publication:No
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Unpublished
Keywords:bone adaptation, mechanostat
Event Title:A refined Mechanostat Model of Bone Transformation
Event Location:Köln, Deutschland
Event Type:international Conference
Event Dates:7.7.-12.Juli 2013
Organizer:IAA
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Mittag, Dr.rer.nat. Uwe
Deposited On:06 Nov 2013 14:58
Last Modified:31 Jul 2019 19:42

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